Evidence map›Paper›PMID 36624285›Full record

Trial reportPediatric research2023

A preconception lifestyle intervention in women with obesity and cardiovascular health in their children.

Tamara den Harink, Joost Schuppen, Maciej Marciniak, Karen A Voet, R Nils Planken, Annemieke Hoek, Henk Groen, Reinoud J B J Gemke, Ben Willem Mol, Nico A Blom and 3 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Tamara den HarinkDepartment of Epidemiology and Data Science, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands. t.denharink@amsterdamumc.nl.
Joost SchuppenDepartment of Radiology and Nuclear Medicine, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands.
Maciej MarciniakDepartment of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Karen A VoetDepartment of Epidemiology and Data Science, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands.
R Nils PlankenDepartment of Radiology and Nuclear Medicine, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands.
Annemieke HoekDepartment of Reproductive Medicine, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
Henk GroenDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Reinoud J B J GemkeDepartment of Paediatrics, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands.
Ben Willem MolDepartment of Obstetrics and Gynaecology, Monash University, Clayton, VIC, Australia.
Nico A BlomDepartment of Paediatric Cardiology, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands.
Pablo LamataDepartment of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Tessa J RoseboomDepartment of Epidemiology and Data Science, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands.
Arend W van DeutekomDepartment of Epidemiology and Data Science, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands.
University of Amsterdam · NLAmsterdam University Medical Centers · NLKing's College London · GBMonash University · AUUniversity Medical Center Groningen · NLUniversity of Groningen · NL

Funding

Wellcome Trust 209450/Z/17/Z
6 · The paper itself

Abstract

backgroundMaternal obesity during pregnancy is associated with poorer cardiovascular health (CVH) in children. A strategy to improve CVH in children could be to address preconception maternal obesity by means of a lifestyle intervention. We determined if a preconception lifestyle intervention in women with obesity improved offspring's CVH, assessed by magnetic resonance imaging (MRI).

methodsWe invited children born to women who participated in a randomised controlled trial assessing the effect of a preconception lifestyle intervention in women with obesity. We assessed cardiac structure, function and geometric shape, pulse wave velocity and abdominal fat tissue by MRI.

resultsWe included 49 of 243 (20.2%) eligible children, 24 girls (49%) girls, mean age 7.1 (0.8) years. Left ventricular ejection fraction was higher in children in the intervention group as compared to children in the control group (63.0% SD 6.18 vs. 58.8% SD 5.77, p = 0.02). Shape analysis showed that intervention was associated with less regional thickening of the interventricular septum and less sphericity. There were no differences in the other outcomes of interest.

conclusionA preconception lifestyle intervention in women with obesity led to a higher ejection fraction and an altered cardiac shape in their offspring, which might suggest a better CVH. IMPACT: A preconception lifestyle intervention in women with obesity results in a higher ejection fraction and an altered cardiac shape that may signify better cardiovascular health (CVH) in their children. This is the first experimental human evidence suggesting an effect of a preconception lifestyle intervention in women with obesity on MRI-derived indicators of CVH in their children. Improving maternal preconception health might prevent some of the detrimental consequences of maternal obesity on CVH in their children.

Indexed as

Pregnancy in ObesityChildFemaleHumansLife StyleMaleObesityPreconception CarePregnancyPulse Wave AnalysisStroke VolumeVentricular Function, Left

Identifiers

PMID36624285
OpenAlexW4313894062

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.