ArticleCardiovascular diabetology2023
Impaired insulin-stimulated myocardial glucose metabolic rate is associated with reduced estimated myocardial energetic efficiency in subjects with different degrees of glucose tolerance.
Article in Cardiovascular diabetology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Coronary flow reserve increase after 4-year dapagliflozin treatment in patients with type 2 diabetes: the DAPAHEART follow-up study.Cardiovascular diabetology · 2025Trial
- Association between liver fibrosis severity and impaired myocardial glucose metabolism in subjects with different degrees of glucose tolerance.BMJ open diabetes research & care · 2026Article
- Association of insulin resistance-related indicators with cardiovascular disease and cardiovascular disease mortality in individuals with MASLD: a population-based study.Therapeutic advances in endocrinology and metabolism · 2026Article
- The Potential Role of Retinol-Binding Protein 4 in Heart Failure: A Review.Reviews in cardiovascular medicine · 2025Review
- A decline in renal function is associated with a reduction in myocardial mechano-energetic efficiency in individuals at high cardiometabolic risk.Cardiovascular diabetology · 2025Article
- The triglyceride glucose (TyG) index is associated with decreased myocardial mechano-energetic efficiency in individuals with different glucose tolerance status.European journal of clinical investigation · 2025Article
- Relationship between hemoglobin glycation index and myocardial mechano-energetic efficiency in non-diabetic individual.Cardiovascular diabetology · 2025Article
- The adverse effect of metabolic syndrome on left ventricular global strains and myocardial energetic efficiency in non-ischemic dilated cardiomyopathy patients: a cardiac magnetic resonance study.Cardiovascular diabetology · 2025Article
- Association between estimated glucose disposal rate with the all-cause and cause-specific mortality among the population with cardiometabolic syndrome.Diabetology & metabolic syndrome · 2025Article
- The additional impact of metabolic syndrome on left ventricular deformation and myocardial energetic efficiency impairment in ischemia with nonobstructive coronary arteries patients.Cardiovascular diabetology · 2025Article
- Association between estimated glucose disposal rate and cardiovascular diseases in patients with diabetes or prediabetes: a cross-sectional study.Cardiovascular diabetology · 2025Article
- Elevated whole blood viscosity is associated with an impaired insulin-stimulated myocardial glucose metabolism.Cardiovascular diabetology · 2024Article
- A Methodology to Measure Glucose Metabolism by Quantitative Analysis of PET Images.Journal of healthcare informatics research · 2024Article
- Non parametric differential network analysis: a tool for unveiling specific molecular signatures.BMC bioinformatics · 2024Article
- Understanding complex systems through differential causal networks.Scientific reports · 2024Article
- Human cardiac metabolism.Cell metabolism · 2024Review
- Sex-specific differences in myocardial glucose metabolic rate in non-diabetic, pre-diabetic and type 2 diabetic subjects.Cardiovascular diabetology · 2024Article
- Endothelial dysfunction is associated with reduced myocardial mechano-energetic efficiency in drug-naïve hypertensive individuals.Internal and emergency medicine · 2023Article
- Cardiac Insulin Resistance in Subjects With Metabolic Syndrome Traits and Early Subclinical Atherosclerosis.Diabetes care · 2023Article
- Myocardial fat accumulation is associated with cardiac dysfunction in patients with type 2 diabetes, especially in elderly or female patients: a retrospective observational study.Cardiovascular diabetology · 2023Observational
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlterations in myocardial mechano-energetic efficiency (MEEi), which represents the capability of the left ventricles to convert the chemical energy obtained by oxidative metabolism into mechanical work, have been associated with cardiovascular disease. Although whole-body insulin resistance has been related to impaired myocardial MEEi, it is unknown the relationship between cardiac insulin resistance and MEEi. Aim of this study was to evaluate the relationship between insulin-stimulated myocardial glucose metabolic rate (MrGlu) and myocardial MEEi in subjects having different degrees of glucose tolerance.
methodsWe evaluated insulin-stimulated myocardial MrGlu using cardiac dynamic positron emission tomography (PET) with
resultsAfter adjusting for age, gender and BMI, subjects in I tertile showed a decrease in myocardial MEEi (0.31 ± 0.05 vs 0.42 ± 0.14 ml/s*g, P = 0.02), and an increase in myocardial oxygen consumption (MVO
conclusionsThese data suggest that an impairment in insulin-stimulated myocardial glucose metabolism is an independent contributor of depressed myocardial MEEi in subjects without history of CHD.
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