Evidence map›Paper›PMID 36625231›Full record

ArticleVeterinary medicine and science2023

Computed tomographic findings in dogs with multiple myeloma.

Sven-Erik Hõim, Ella Fitzgerald, Emma Mapletoft, Katarzyna Purzycka

Open access · goldAbstract read
In one paragraph

Article in Veterinary medicine and science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Sven-Erik HõimDiagnostic Imaging Department, Anderson Moores Veterinary Specialists Part of Linnaeus Veterinary Limited, The Granary, Bunstead Barns, Poles Ln, Winchester, UK.ORCID 0000-0002-4783-0525
Ella FitzgeraldANTECH Imaging Services, Fountain Valley, California.
Emma MapletoftDiagnostic Imaging Department, Queen Mother Hospital for Animals, Royal Veterinary College, North Mymms, Hertfordshire, UK.
Katarzyna PurzyckaOncology Department, Lumbry Park Veterinary Specialists, Alton, Hampshire, UK.
Carolina Veterinary Specialists · USRoyal Veterinary College · GBValley Regional Hospital · USWillows Veterinary Centre and Referral Service · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComputed tomography (CT) is considered the first-line imaging modality for human patients with suspected multiple myeloma (MM). Recently the diagnostic criteria for human MM have been updated.

objectivesTo describe and provide a baseline of the CT features and distribution of osseous lesions in dogs diagnosed with MM and to describe the change of initial osseous lesions after the start of treatment in a subset of dogs.

methodsSingle-centre, retrospective, descriptive, case series. Dogs were included when they met the updated MM criteria and if a staging CT was performed at the time of diagnosis and prior to initiation of treatment. When available, change of osseous lesions was assessed on serial imaging studies.

resultsThirteen dogs met the inclusion criteria. All dogs had involvement of the axial skeleton and 9/13 (69%) had concurrent involvement of the appendicular skeleton. Large (≥1 cm), lytic, 'punched out' or expansile bony lesions and regions of permeative lysis were most common and mainly affected the vertebral column. Discrete intramedullary soft tissue attenuating lesions of the proximal appendicular skeleton were observed in 8/13 dogs (61%) and bilateral involvement of both humeri and femurs was seen in 4/9 dogs (44%). A subset of dogs underwent serial imaging and progressive replacement of the contrast-enhancing lesions with fat attenuating tissue was observed for all dogs, corresponding with clinical improvement.

conclusionsThis case series provides a baseline knowledge of the initial and follow-up CT features in dogs diagnosed with MM based on updated criteria.

Indexed as

Bone DiseasesDog DiseasesMultiple MyelomaAnimalsBone and BonesDogsHumansRetrospective StudiesTomography, X-Ray Computedcomputed tomographydogmultiple myeloma

Identifiers

PMID36625231
PMCPMC10029888
OpenAlexW4313907323

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.