Evidence map›Paper›PMID 36625320›Full record

ArticleThe Journal of physiology2023

Impaired dendritic spike generation in the Fragile X prefrontal cortex is due to loss of dendritic sodium channels.

Federico Brandalise, Brian E Kalmbach, Erik P Cook, Darrin H Brager

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Federico BrandaliseCenter for Learning and Memory, University of Texas at Austin, Austin, TX, USA.
Brian E KalmbachCenter for Learning and Memory, University of Texas at Austin, Austin, TX, USA.
Erik P CookDepartment of Physiology, McGill University, Montreal, QC, Canada.ORCID 0000-0002-6516-1927
Darrin H BragerCenter for Learning and Memory, University of Texas at Austin, Austin, TX, USA.ORCID 0000-0002-3736-0515
Allen Institute for Brain Science · USMcGill University · CAThe University of Texas at Austin · USUniversity of Milan · IT

Funding

Hippocampal channelopathies in Fragile X SyndromeR01MH100510 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI BRAGER, DARRIN H · 2015 to 2019
$1.9M
Hippocampal channelopathies in Fragile X SyndromeR56MH100510 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI BRAGER, DARRIN H · 2020 to 2020
$441k
NIH HHS R01/R56 MH100510NIMH NIH HHS R01 MH100510NIMH NIH HHS R56 MH100510Swiss National Science Foundation P2ZHP3_168621Swiss National Science Foundation P400PB_180785
6 · The paper itself

Abstract

Patients with Fragile X syndrome, the leading monogenetic cause of autism, suffer from impairments related to the prefrontal cortex, including working memory and attention. Synaptic inputs to the distal dendrites of layer 5 pyramidal neurons in the prefrontal cortex have a weak influence on the somatic membrane potential. To overcome this filtering, distal inputs are transformed into local dendritic Na

Indexed as

Fragile X SyndromeAction PotentialsAnimalsDendritesFragile X Messenger Ribonucleoprotein 1MaleMiceNeuronsPrefrontal CortexPyramidal CellsSodium ChannelsFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1Sodium ChannelsdendritePFCvoltage-gated channel

Identifiers

PMID36625320
PMCPMC9970745
OpenAlexW4315436996

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.