Evidence map›Paper›PMID 36627698›Full record

ReviewMolecular cancer2023

Clinical application and detection techniques of liquid biopsy in gastric cancer.

Shuo Ma, Meiling Zhou, Yanhua Xu, Xinliang Gu, Mingyuan Zou, Gulinaizhaer Abudushalamu, Yuming Yao, Xiaobo Fan, Guoqiu Wu

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Molecular cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06490159 (Predicting Peripheral Neuropathy of Paclitaxel in Second-line Chemotherapy for Gastric Cancer), which is not on this map. Cited by 122 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed, 3 pooled it
40.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06490159 recruitingnot on this map

Predicting Peripheral Neuropathy of Paclitaxel in Second-line Chemotherapy for Gastric Cancer

TypeobservationalSponsorCity of Hope Medical CenterRan2018 to 2028Enrolled150ConditionsGastric Cancer, Chemotherapy-induced Peripheral Neuropathy, Paclitaxel, RamucirumabArmsPaclitaxel
3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 3 syntheses or guidelines pooled it, 169 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. [Bottlenecks and breakthroughs in gastric cancer diagnosis and treatment: Towards a new era of precision and intelligent integration].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026
    Review
  13. Review
  14. [Next-Generation Sequencing-Based Detection of Gene Mutations and Its Association With Clinicopathological Features in Gastric Cancer].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Article
  15. Article
  16. Article
  17. Novel Liquid Biopsy in Gastrointestinal Cancers.Journal of gastroenterology and hepatology · 2026
    Review
  18. Article
  19. Article
  20. Article

62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Shuo Ma *Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, Jiangsu, China.
Meiling Zhou *Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, Jiangsu, China.
Yanhua XuDepartment of Laboratory Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225000, Jiangsu, China.
Xinliang GuDepartment of Laboratory Medicine, Medical School, Affiliated Hospital of Nantong University, Nantong University, Nantong, 226001, Jiangsu, China.
Mingyuan ZouCenter of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, Jiangsu, China.
Gulinaizhaer AbudushalamuCenter of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, Jiangsu, China.
Yuming YaoCenter of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, Jiangsu, China.
Xiaobo FanCenter of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, Jiangsu, China.
Guoqiu WuCenter of Clinical Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, Jiangsu, China. 101008404@seu.edu.cn.
Southeast University · CNZhongda Hospital Southeast University · CNAffiliated Hospital of Nantong University · CNNorthern Jiangsu People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC) is one of the most common tumors worldwide and the leading cause of tumor-related mortality. Endoscopy and serological tumor marker testing are currently the main methods of GC screening, and treatment relies on surgical resection or chemotherapy. However, traditional examination and treatment methods are more harmful to patients and less sensitive and accurate. A minimally invasive method to respond to GC early screening, prognosis monitoring, treatment efficacy, and drug resistance situations is urgently needed. As a result, liquid biopsy techniques have received much attention in the clinical application of GC. The non-invasive liquid biopsy technique requires fewer samples, is reproducible, and can guide individualized patient treatment by monitoring patients' molecular-level changes in real-time. In this review, we introduced the clinical applications of circulating tumor cells, circulating free DNA, circulating tumor DNA, non-coding RNAs, exosomes, and proteins, which are the primary markers in liquid biopsy technology in GC. We also discuss the current limitations and future trends of liquid biopsy technology as applied to early clinical biopsy technology.

Indexed as

Neoplastic Cells, CirculatingStomach NeoplasmsBiomarkers, TumorBiopsyDNA, NeoplasmHumansLiquid BiopsyPrognosisBiomarkers, TumorDNA, NeoplasmCirculating tumor cellsCirculating tumor DNAExosomesGastric cancerLiquid biopsyNon-coding RNAs

Identifiers

PMID36627698
PMCPMC9832643
OpenAlexW4315487575

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.