Evidence map›Paper›PMID 36630902›Full record

ReviewStem cell reports2023

Biophysical models of early mammalian embryogenesis.

Alaina Cockerell, Liam Wright, Anish Dattani, Ge Guo, Austin Smith, Krasimira Tsaneva-Atanasova, David M Richards

Abstract readReview
In one paragraph

Review in Stem cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alaina CockerellLiving Systems Institute, University of Exeter, Stocker Road, Exeter EX4 4QD, UK.
Liam WrightDepartment of Mathematics, University of Exeter, North Park Road, Exeter EX4 4QF, UK.
Anish DattaniLiving Systems Institute, University of Exeter, Stocker Road, Exeter EX4 4QD, UK.
Ge GuoLiving Systems Institute, University of Exeter, Stocker Road, Exeter EX4 4QD, UK.
Austin SmithLiving Systems Institute, University of Exeter, Stocker Road, Exeter EX4 4QD, UK.
Krasimira Tsaneva-AtanasovaLiving Systems Institute, University of Exeter, Stocker Road, Exeter EX4 4QD, UK; Department of Mathematics, University of Exeter, North Park Road, Exeter EX4 4QF, UK; EPSRC Hub for Quantitative Modelling in Healthcare, University of Exeter, Exeter EX4 4QJ, UK; Department of Bioinformatics and Mathematical Modelling, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 105 Acad. G. Bonchev Street, 1113 Sofia, Bulgaria.
David M RichardsLiving Systems Institute, University of Exeter, Stocker Road, Exeter EX4 4QD, UK; Department of Physics and Astronomy, University of Exeter, North Park Road, Exeter EX4 4QL, UK. Electronic address: david.richards@exeter.ac.uk.

Funding

Biotechnology and Biological Sciences Research Council BB/V017128/1Medical Research Council G1100526/2Medical Research Council MR/P022405/1Medical Research Council MR/W025310/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/X002268/1
6 · The paper itself

Abstract

Embryo development is a critical and fascinating stage in the life cycle of many organisms. Despite decades of research, the earliest stages of mammalian embryogenesis are still poorly understood, caused by a scarcity of high-resolution spatial and temporal data, the use of only a few model organisms, and a paucity of truly multidisciplinary approaches that combine biological research with biophysical modeling and computational simulation. Here, we explain the theoretical frameworks and biophysical processes that are best suited to modeling the early mammalian embryo, review a comprehensive list of previous models, and discuss the most promising avenues for future work.

Indexed as

BlastocystEmbryo, MammalianAnimalsEmbryonic DevelopmentMammalsbiophysical modelingblastocystblastoidcomputational simulationembryogenesis

Identifiers

PMID36630902
PMCPMC9860129

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.