Evidence map›Paper›PMID 36632503›Full record

ArticleBioactive materials2023

Mechano-responsive hydrogel for direct stem cell manufacturing to therapy.

Yufeng Shou, Ling Liu, Qimin Liu, Zhicheng Le, Khang Leng Lee, Hua Li, Xianlei Li, Dion Zhanyun Koh, Yuwen Wang, Tong Ming Liu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. The Rise of Mechanobiology for Advanced Cell Engineering and Manufacturing.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yufeng ShouDepartment of Biomedical Engineering, National University of Singapore, 117583, Singapore.
Ling LiuInstitute for Health Innovation & Technology, National University of Singapore, 117599, Singapore.
Qimin LiuSchool of Civil Engineering and Architecture, Wuhan University of Technology, 430070, Wuhan, China.
Zhicheng LeDepartment of Biomedical Engineering, National University of Singapore, 117583, Singapore.
Khang Leng LeeLee Kong Chian School of Medicine, Nanyang Technological University, 636921, Singapore.
Hua LiSchool of Mechanical and Aerospace Engineering, Nanyang Technological University, 639798, Singapore.
Xianlei LiDepartment of Biomedical Engineering, National University of Singapore, 117583, Singapore.
Dion Zhanyun KohDepartment of Biomedical Engineering, National University of Singapore, 117583, Singapore.
Yuwen WangDepartment of Biomedical Engineering, National University of Singapore, 117583, Singapore.
Tong Ming LiuInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (ASTAR), 138648, Singapore.
Zheng YangNUS Tissue Engineering Program, National University of Singapore, 117510, Singapore.
Chwee Teck LimDepartment of Biomedical Engineering, National University of Singapore, 117583, Singapore.
Christine CheungLee Kong Chian School of Medicine, Nanyang Technological University, 636921, Singapore.
Andy TayDepartment of Biomedical Engineering, National University of Singapore, 117583, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone marrow-derived mesenchymal stem cell (MSC) is one of the most actively studied cell types due to its regenerative potential and immunomodulatory properties. Conventional cell expansion methods using 2D tissue culture plates and 2.5D microcarriers in bioreactors can generate large cell numbers, but they compromise stem cell potency and lack mechanical preconditioning to prepare MSC for physiological loading expected

Indexed as

Cell therapyDMS, Dynamic Mechanical StimulationDynamic mechanical stimulationMagnetic hydrogelMesenchymal stem cellMP, Magnetic ParticleMSC, Mesenchymal Stem CellStem cell manufacturing

Identifiers

PMID36632503
PMCPMC9817177

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.