Evidence map›Paper›PMID 36633253›Full record

ArticleAging cell2023

SATB2, coordinated with CUX1, regulates IL-1β-induced senescence-like phenotype in endothelial cells by fine-tuning the atherosclerosis-associated p16

Ting Wu, Yuwei Wu, Danli Jiang, Wei Sun, Meijuan Zou, Sathish Babu Vasamsetti, Partha Dutta, Steven A Leers, Wu Di, Gang Li

Open access · goldAbstract read
In one paragraph

Article in Aging cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 13 citations in OpenAlex.

  1. Multicellular senescence programs in the aged heart.Journal of molecular and cellular cardiology plus · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. PCBP2 Regulates p16Aging cell · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Ting WuDepartment of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yuwei WuAging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Danli JiangAging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Wei SunCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pennsylvania, Pittsburgh, USA.
Meijuan ZouAging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Sathish Babu VasamsettiCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pennsylvania, Pittsburgh, USA.
Partha DuttaCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pennsylvania, Pittsburgh, USA.
Steven A LeersUPMC Vascular Laboratories, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Wu DiDepartment of Periodontology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Gang LiAging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-1725-6611
University of Pittsburgh · USCentral South University · CNUniversity of North Carolina at Chapel Hill · USUniversity of Pittsburgh Medical Center · US

Funding

Comprehensive functional genomic analysis of the multi-disease associated CDKN2A/B locusR01AG065229 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FINKEL, TOREN, LI, GANG · 2021 to 2025
$2.9M
fSNP-seq and DCP-MS as a New Approach to Study AD-associated, Non-coding Functional SNP's in a Post GWAS EraR01AG056279 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LI, GANG · 2017 to 2019
$1.7M
Identifying and Characterizing the Functional SNPs on RA-Associated loci involved in CD40/NF-kB SignalR21AR070378 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LI, GANG · 2017 to 2018
$391k
NIA NIH HHS R01 AG065229
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) have validated a strong association of atherosclerosis with the CDKN2A/B locus, a locus harboring three tumor suppressor genes: p14

Indexed as

AtherosclerosisMatrix Attachment Region Binding ProteinsCellular SenescenceCyclin-Dependent Kinase Inhibitor p16Endothelial CellsGenome-Wide Association StudyHomeodomain ProteinsHumansInterferon beta-1bPhenotypeRepressor ProteinsTranscription FactorsCUX1 protein, humanCyclin-Dependent Kinase Inhibitor p16Homeodomain ProteinsInterferon beta-1bMatrix Attachment Region Binding ProteinsRepressor ProteinsSATB2 protein, humanTranscription Factorsagingaging-related diseasesatherosclerosiscellular senescenceendothelial cellspost-GWAS functional analysissenescence-associated secretory phenotype (SASP)single nucleotide polymorphism (SNP)

Identifiers

PMID36633253
PMCPMC9924951
OpenAlexW4315752923

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.