Evidence map›Paper›PMID 36634048›Full record

ReviewPLoS pathogens2023

Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities.

Rahul Kumar, Öznur Aktay-Cetin, Vaughn Craddock, Daniel Morales-Cano, Djuro Kosanovic, Angel Cogolludo, Francisco Perez-Vizcaino, Sergey Avdeev, Ashok Kumar, Anil Kumar Ram and 7 more

Open access · goldAbstract readReview
In one paragraph

Review in PLoS pathogens, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  4. Review
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  7. Article
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  9. Article
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  11. Long COVID: Molecular Mechanisms and Detection Techniques.International journal of molecular sciences · 2023
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 6 countries.

Rahul KumarDepartment of Medicine, University of California San Francisco, San Francisco, California, United States of America.
Öznur Aktay-CetinMax Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany.
Vaughn CraddockDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America.
Daniel Morales-CanoCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Djuro KosanovicDepartment of Pulmonology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Angel CogolludoDepartment of Pharmacology and Toxicology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain.
Francisco Perez-VizcainoDepartment of Pharmacology and Toxicology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain.
Sergey AvdeevDepartment of Pulmonology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Ashok KumarDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America.
Anil Kumar RamDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America.
Stuti AgarwalDivision of Pulmonary, Allergy, and Critical Care Medicine, Stanford University Medical Center, California, United States of America.
Ananya ChakrabortyDivision of Pulmonary, Allergy, and Critical Care Medicine, Stanford University Medical Center, California, United States of America.
Rajkumar SavaiMax Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany.
Vinicio de Jesus PerezDivision of Pulmonary, Allergy, and Critical Care Medicine, Stanford University Medical Center, California, United States of America.
Brian B GrahamDepartment of Medicine, University of California San Francisco, San Francisco, California, United States of America.
Ghazwan ButrousCardiopulmonary Sciences, University of Kent, Canterbury, United Kingdom.
Navneet K DhillonDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America.ORCID 0000-0001-6582-5757
University of Kansas Medical Center · USStanford Medicine · USSan Francisco General Hospital · USSechenov University · RUUniversidad Complutense de Madrid · ESAarhus University · DKGoethe University Frankfurt · DEJustus-Liebig-Universität Gießen · DEUniversity of Kent · GB

Funding

Role of Complement-Driven Pulmonary Vascular Inflammation in PHP01HL152961 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI DELANEY, CASSIDY A · 2020 to 2024
$14.1M
Investigating paclitaxel treatment in a pre-clinical model of Schistosoma-pulmonary hypertensionR01HL135872 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Brian Barkley Graham · 2017 to 2026
$5.1M
Drug abuse and HIV-associated pulmonary vascular injuryR01HL152832 · NHLBI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI DHILLON, NAVNEET KAUR · 2021 to 2024
$2.8M
Impact of Opiate abuse on HIV-mediated Pulmonary Vascular RemodelingR01HL129875 · NHLBI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI DHILLON, NAVNEET KAUR · 2016 to 2018
$1.5M
NHLBI NIH HHS P01 HL152961NHLBI NIH HHS R01 HL129875NHLBI NIH HHS R01 HL135872NHLBI NIH HHS R01 HL152832
6 · The paper itself

Abstract

The Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and its sublineages pose a new challenge to healthcare systems worldwide due to its ability to efficiently spread in immunized populations and its resistance to currently available therapies. COVID-19, although targeting primarily the respiratory system, is also now well established that later affects every organ in the body. Most importantly, despite the available therapy and vaccine-elicited protection, the long-term consequences of viral infection in breakthrough and asymptomatic individuals are areas of concern. In the past two years, investigators accumulated evidence on how the virus triggers our immune system and the molecular signals involved in the cross-talk between immune cells and structural cells in the pulmonary vasculature to drive pathological lung complications such as endothelial dysfunction and thrombosis. In the review, we emphasize recent updates on the pathophysiological inflammatory and immune responses associated with SARS-CoV-2 infection and their potential long-term consequences that may consequently lead to the development of pulmonary vascular diseases.

Indexed as

CoinfectionCOVID-19Cross ReactionsHumansLungSARS-CoV-2

Identifiers

PMID36634048
PMCPMC9836319
OpenAlexW4315754623

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.