Evidence map›Paper›PMID 36634338›Full record

ArticleApplied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme2023

Akt substrate of 160 kDa is essential for the calorie restriction-induced increase in insulin-stimulated glucose uptake by skeletal muscle of female rats.

Amy Zheng, Haiyan Wang, Edward B Arias, Gengfu Dong, Jiahui Zhao, Gregory D Cartee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Sex-specific phosphoproteome responses to calorie restriction and insulin in skeletal muscle from older rats.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Amy ZhengMuscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, MI, USA.
Haiyan WangMuscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, MI, USA.
Edward B AriasMuscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, MI, USA.
Gengfu DongMuscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, MI, USA.
Jiahui ZhaoMuscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, MI, USA.
Gregory D CarteeMuscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-5311-1722
Mie University · JP

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Aging, Calorie Restriction, Exercise and Insulin SensitivityR01AG010026 · NIA · UNIVERSITY OF WISCONSIN MADISON · PI CARTEE, GREGORY D. · 1998 to 2023
$6.8M
NIA NIH HHS R01 AG010026NIDDK NIH HHS P30 DK020572
6 · The paper itself

Abstract

We evaluated effects of calorie restriction (CR; consuming 65% of ad libitum (AL) intake) for 8 weeks on female wildtype (WT) and Akt substrate of 160 kDa knockout (AS160-KO) rats. Insulin-stimulated glucose uptake (ISGU) was determined in isolated epitrochlearis muscles incubated with 0, 50, 100, or 500 µU/mL insulin. Phosphorylation of key insulin signaling proteins that control ISGU (Akt and AS160) was assessed by immunoblotting (Akt phosphorylation on Threonine-308, pAkt

Indexed as

GlucoseInsulinAnimalsCaloric RestrictionFemaleGlucose Transporter Type 4GTPase-Activating ProteinsMuscle, SkeletalPhosphorylationProto-Oncogene Proteins c-aktRatsSerineThreonineGlucoseGlucose Transporter Type 4GTPase-Activating ProteinsInsulinProto-Oncogene Proteins c-aktSerineTBC1D4 protein, ratThreonineglucose transportGLUT4insulin resistanceinsulin sensitivity

Identifiers

PMID36634338
PMCPMC11726319
OpenAlexW4315778707

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.