Evidence map›Paper›PMID 36635111›Full record

ReviewTrends in neurosciences2023

Unraveling the dynamics of dopamine release and its actions on target cells.

Tanya Sippy, Nicolas X Tritsch

Open access · greenAbstract readReview
In one paragraph

Review in Trends in neurosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 64 citations in OpenAlex.

  1. The Cellular and Synaptic Actions of Dopamine During Behavior.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
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  8. A next generation neural mass model with neuromodulation.Journal of computational neuroscience · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Dynamic changes of dopamine neuron activity and plasticity at different stages of negative reinforcement learning.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Refining the role of the paraventricular hypothalamus in feeding behavior.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Tanya SippyNeuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA; Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: Tanya.Sippy@nyulangone.org.
Nicolas X TritschNeuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA; Fresco Institute for Parkinson's and Movement Disorders, New York University Langone Health, New York, NY, USA. Electronic address: Nicolas.Tritsch@nyulangone.org.
New York University · USNYU Langone Health · US

Funding

Dissecting the Synaptic and Cellular Actions of Dopamine in Vivo - Diversity SupplementR01MH130658 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Tanya Sippy · 2022 to 2026
$3.5M
Sensory Plasticity in the Auditory Striatum as an Impetus for Action Control - Diversity SupplementR01NS126391 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Tanya Sippy · 2022 to 2026
$2.6M
A novel framework for the functional dissection of motor systemsDP2NS105553 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TRITSCH, NICOLAS XAVIER · 2017 to 2017
$2.5M
NIMH NIH HHS R01 MH130658NINDS NIH HHS DP2 NS105553NINDS NIH HHS R01 NS126391
6 · The paper itself

Abstract

The neuromodulator dopamine (DA) is essential for regulating learning, motivation, and movement. Despite its importance, however, the mechanisms by which DA influences the activity of target cells to alter behavior remain poorly understood. In this review, we describe recent methodological advances that are helping to overcome challenges that have historically hindered the field. We discuss how the employment of these methods is shedding light on the complex dynamics of extracellular DA in the brain, as well as how DA signaling alters the electrical, biochemical, and population activity of target neurons in vivo. These developments are generating novel hypotheses about the mechanisms through which DA release modifies behavior.

Indexed as

DopamineLearningBrainHumansMotivationNeuronsRewardDopamineexcitabilitymovementneuromodulationreinforcement learningrewardstriatumsynaptic plasticity

Identifiers

PMID36635111
PMCPMC10204099
OpenAlexW4313892024

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.