Evidence map›Paper›PMID 36635451›Full record

ArticleNature plants2023

Adaptor protein complex interaction map in Arabidopsis identifies P34 as a common stability regulator.

Peng Wang, Wei Siao, Xiuyang Zhao, Deepanksha Arora, Ren Wang, Dominique Eeckhout, Jelle Van Leene, Rahul Kumar, Anaxi Houbaert, Nancy De Winne and 9 more

Open access · greenAbstract read
In one paragraph

Article in Nature plants, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Cargo Sorting Zones in Plant Trans-Golgi Network.Sub-cellular biochemistry · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 4 countries.

Peng Wang *Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0002-5573-2722
Wei Siao *Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium. wei.siao@psb.vib-ugent.be.ORCID http://orcid.org/0000-0003-0758-657X
Xiuyang ZhaoDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.
Deepanksha AroraDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.
Ren WangDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.
Dominique EeckhoutDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0001-5770-7670
Jelle Van LeeneDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0002-4932-8192
Rahul KumarDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.
Anaxi HoubaertDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.
Nancy De WinneDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.
Evelien MylleDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0002-3690-4365
Michael VandorpeDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0001-8936-4174
Ruud A KorverPlant Physiology and Cell Biology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands.
Christa TesterinkPlant Physiology and Cell Biology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0001-6738-115X
Kris GevaertDepartment of Biomolecular Medicine, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0002-4237-0283
Steffen VannesteDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0002-9948-9672
Geert De JaegerDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.
Daniël Van DammeDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0002-9385-4851
Eugenia RussinovaDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium. eurus@psb.vib-ugent.be.ORCID http://orcid.org/0000-0002-0569-1977
Ghent University · BEUniversity of Amsterdam · NL

Funding

EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 682436Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders) 3G038020Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G008416NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G0E5718N
6 · The paper itself

Abstract

Adaptor protein (AP) complexes are evolutionarily conserved vesicle transport regulators that recruit coat proteins, membrane cargoes and coated vesicle accessory proteins. As in plants endocytic and post-Golgi trafficking intersect at the trans-Golgi network, unique mechanisms for sorting cargoes of overlapping vesicular routes are anticipated. The plant AP complexes are part of the sorting machinery, but despite some functional information, their cargoes, accessory proteins and regulation remain largely unknown. Here, by means of various proteomics approaches, we generated the overall interactome of the five AP and the TPLATE complexes in Arabidopsis thaliana. The interactome converged on a number of hub proteins, including the thus far unknown adaptin binding-like protein, designated P34. P34 interacted with the clathrin-associated AP complexes, controlled their stability and, subsequently, influenced clathrin-mediated endocytosis and various post-Golgi trafficking routes. Altogether, the AP interactome network offers substantial resources for further discoveries of unknown endomembrane trafficking regulators in plant cells.

Indexed as

ArabidopsisArabidopsis ProteinsClathrinGolgi Apparatustrans-Golgi NetworkArabidopsis ProteinsClathrin

Identifiers

PMID36635451
PMCPMC7615410
OpenAlexW4315779438

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.