Evidence map›Paper›PMID 36635734›Full record

ArticleEnvironmental health : a global access science source2023

A science-based agenda for health-protective chemical assessments and decisions: overview and consensus statement.

Tracey J Woodruff, Swati D G Rayasam, Daniel A Axelrad, Patricia D Koman, Nicholas Chartres, Deborah H Bennett, Linda S Birnbaum, Phil Brown, Courtney C Carignan, Courtney Cooper and 38 more

Open access · goldAbstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health : a global access science source, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
27.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors at 20 institutions in 2 countries.

Tracey J WoodruffProgram On Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 490 Illinois Street, Floor 10, Box 0132, San Francisco, CA, 94143, USA. Tracey.Woodruff@ucsf.edu.
Swati D G RayasamProgram On Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 490 Illinois Street, Floor 10, Box 0132, San Francisco, CA, 94143, USA.
Daniel A AxelradIndependent Consultant, Washington, DC, USA.
Patricia D KomanDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Nicholas ChartresProgram On Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 490 Illinois Street, Floor 10, Box 0132, San Francisco, CA, 94143, USA.
Deborah H BennettDepartment of Public Health Sciences, University of California, Davis, Davis, CA, USA.
Linda S BirnbaumNational Institutes of Environmental Health Sciences and National Toxicology Program, Research Triangle Park, NC, USA.
Phil BrownSocial Science Environmental Health Research Institute, Northeastern University, Boston, MA, USA.
Courtney C CarignanDepartment of Food Science and Human Nutrition, Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA.
Courtney CooperProgram On Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 490 Illinois Street, Floor 10, Box 0132, San Francisco, CA, 94143, USA.
Carl F CranorDepartment of Philosophy, University of California, Riverside, Riverside, CA, USA.
Miriam L DiamondDepartment of Earth Sciences, University of Toronto, Toronto, ON, Canada.
Shari FranjevicClean Production Action, Somerville, MA, USA.
Eve C GartnerEarthjustice, New York, NY, USA.
Dale HattisThe George Perkins Marsh Institute, Clark University, Worcester, MA, USA.
Russ HauserDepartment of Environmental Health, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Wendy Heiger-BernaysDepartment of Environmental Health, School of Public Health, Boston University, Boston, MA, USA.
Rashmi JoglekarEarthjustice, New York, NY, USA.
Juleen LamDepartment of Public Health, California State University, East Bay, Hayward, CA, USA.
Jonathan I LevyDepartment of Environmental Health, School of Public Health, Boston University, Boston, MA, USA.
Patrick M MacRoyDefend Our Health, Portland, ME, USA.
Maricel V MaffiniIndependent Consultant, Washington, DC, USA.
Emily C MarquezPesticide Action Network, Berkeley, CA, USA.
Rachel Morello-FroschSchool of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Keeve E NachmanDepartment of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Greylin H NielsenDepartment of Environmental Health, School of Public Health, Boston University, Boston, MA, USA.
Catherine OksasSchool of Medicine, University of California, San Francisco, CA, USA.
Dimitri Panagopoulos AbrahamssonProgram On Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 490 Illinois Street, Floor 10, Box 0132, San Francisco, CA, 94143, USA.
Heather B PatisaulDepartment of Biological Sciences, Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, USA.
Sharyle Patton, Commonweal, Bolinas, CA, USA.
Joshua F RobinsonProgram On Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 490 Illinois Street, Floor 10, Box 0132, San Francisco, CA, 94143, USA.
Kathryn M RodgersSilent Spring Institute, Newton, MA, USA.
Mark S RossiClean Production Action, Somerville, MA, USA.
Ruthann A RudelSilent Spring Institute, Newton, MA, USA.
Jennifer B SassNatural Resources Defense Council, Washington, DC, USA.
Sheela SathyanarayanaDepartment of Pediatrics, University of Washington, Seattle, WA, USA.
Ted SchettlerScience and Environmental Health Network, Ames, IA, USA.
Rachel M ShafferDepartment of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle, USA.
Bhavna ShamasunderDepartment of Urban & Environmental Policy and Public Health, Occidental College, Los Angeles, CA, USA.
Peggy M ShepardWE ACT for Environmental Justice, New York, NY, USA.
Kristin Shrader-FrechetteDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.
Gina M SolomonSchool of Medicine, University of California, San Francisco, CA, USA.
Wilma A SubraLouisiana Environmental Action Network, Baton Rouge, LA, USA.
Laura N VandenbergDepartment of Environmental Health Sciences, School of Public Health & Health Sciences, University of Massachusetts, Amherst, Amherst, MA, USA.
Julia R VarshavskyDepartment of Health Sciences, Northeastern University, Boston, MA, USA.
Roberta F WhiteDepartment of Environmental Health, School of Public Health, Boston University, Boston, MA, USA.
Ken ZarkerWashington State Department of Ecology, Olympia, WA, USA.
Lauren ZeiseOffice of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, CA, USA.
University of California, San Francisco · USAction Network · USEarthjustice · USIndependent Sector · USNortheastern University · USSilent Spring Institute · USUniversity of Washington · USBerkeley Public Health Division · USCalifornia Environmental Protection Agency · USCalifornia State University, East Bay · USClark University · USCommonweal · USDuke University · USHarvard University · USHealth Net · USInternational Center for Transitional Justice · USJohns Hopkins University · USMichigan State University · USNatural Resources Defense Council · USNorth Carolina State University · US

Funding

Training CoreP42ES004705 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI SMITH, MARTYN T · 1987 to 2025
$74.6M
Training CoreP42ES007381 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ASCHENGRAU, ANN · 1995 to 2019
$46.1M
UC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Ameer Taha · 2015 to 2026
$26.0M
Translational Research Support CoreP30ES025128 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Kelly Sides · 2015 to 2026
$18.3M
UCSF Environmental Research and Translation for Health Center (EaRTH Center)P30ES030284 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JENNIFER C FUNG, Tracey J. Woodruff · 2020 to 2026
$11.2M
Environmental Epidemiology in Community SettingsT32ES014562 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Birgit Gunhild Claus Henn · 2006 to 2026
$7.7M
Fine particulate air pollution, neuropathologies, and Alzheimers disease.F31ES030972 · NIEHS · UNIVERSITY OF WASHINGTON · PI SHAFFER, RACHEL · 2019 to 2019
$45k
NIEHS NIH HHS F31 ES030972NIEHS NIH HHS P30 ES023513NIEHS NIH HHS P30 ES025128NIEHS NIH HHS P30 ES030284NIEHS NIH HHS P42 ES004705NIEHS NIH HHS P42 ES007381NIEHS NIH HHS T32 ES014562
6 · The paper itself

Abstract

The manufacture and production of industrial chemicals continues to increase, with hundreds of thousands of chemicals and chemical mixtures used worldwide, leading to widespread population exposures and resultant health impacts. Low-wealth communities and communities of color often bear disproportionate burdens of exposure and impact; all compounded by regulatory delays to the detriment of public health. Multiple authoritative bodies and scientific consensus groups have called for actions to prevent harmful exposures via improved policy approaches. We worked across multiple disciplines to develop consensus recommendations for health-protective, scientific approaches to reduce harmful chemical exposures, which can be applied to current US policies governing industrial chemicals and environmental pollutants. This consensus identifies five principles and scientific recommendations for improving how agencies like the US Environmental Protection Agency (EPA) approach and conduct hazard and risk assessment and risk management analyses: (1) the financial burden of data generation for any given chemical on (or to be introduced to) the market should be on the chemical producers that benefit from their production and use; (2) lack of data does not equate to lack of hazard, exposure, or risk; (3) populations at greater risk, including those that are more susceptible or more highly exposed, must be better identified and protected to account for their real-world risks; (4) hazard and risk assessments should not assume existence of a "safe" or "no-risk" level of chemical exposure in the diverse general population; and (5) hazard and risk assessments must evaluate and account for financial conflicts of interest in the body of evidence. While many of these recommendations focus specifically on the EPA, they are general principles for environmental health that could be adopted by any agency or entity engaged in exposure, hazard, and risk assessment. We also detail recommendations for four priority areas in companion papers (exposure assessment methods, human variability assessment, methods for quantifying non-cancer health outcomes, and a framework for defining chemical classes). These recommendations constitute key steps for improved evidence-based environmental health decision-making and public health protection.

Indexed as

Environmental PollutantsConsensus Statements as TopicEnvironmental ExposureEnvironmental HealthHumansPublic HealthRisk AssessmentEnvironmental PollutantsChemicalsConflicts of InterestEnvironmental HealthEnvironmental JusticeEPAHazard IdentificationHealth EquityRisk AssessmentTSCA

Identifiers

PMID36635734
PMCPMC9835243
OpenAlexW4315796166

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.