Evidence map›Paper›PMID 36645634›Full record

ArticleFrontiers of medicine2023

Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma.

Jing Feng, Zheng Zhao, Yanfei Wei, Zhaoshi Bao, Wei Zhang, Fan Wu, Guanzhang Li, Zhiyan Sun, Yanli Tan, Jiuyi Li and 13 more

Abstract read
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Article in Frontiers of medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Jing Feng *Beijing Key Laboratory of Gene Resource and Molecular Development, Laboratory of Neuroscience and Brain Development, Beijing Normal University, Beijing, 100875, China.
Zheng Zhao *Beijing Neurosurgical Institute, Beijing, 100070, China.
Yanfei Wei *Beijing Key Laboratory of Gene Resource and Molecular Development, Laboratory of Neuroscience and Brain Development, Beijing Normal University, Beijing, 100875, China.
Zhaoshi Bao *Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Wei ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Fan WuBeijing Neurosurgical Institute, Beijing, 100070, China.
Guanzhang LiBeijing Neurosurgical Institute, Beijing, 100070, China.
Zhiyan SunBeijing Neurosurgical Institute, Beijing, 100070, China.
Yanli TanDepartment of Pathology, Affiliated Hospital of Hebei University, Baoding, 071000, China.
Jiuyi LiGendya Biotechnology Ltd., Beijing, 100176, China.
Yunqiu ZhangCenter of Growth Metabolism & Aging, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610065, China.
Zejun DuanDepartment of Pathology, Sanbo Brain Hospital, Capital Medical University, Beijing, 100093, China.
Xueling QiDepartment of Pathology, Sanbo Brain Hospital, Capital Medical University, Beijing, 100093, China.
Kai YuBiodynamic Optical Imaging Center (BIOPIC), School of Life Sciences, Peking University, Beijing, 100871, China.
Zhengmin CongBeijing Key Laboratory of Gene Resource and Molecular Development, Laboratory of Neuroscience and Brain Development, Beijing Normal University, Beijing, 100875, China.
Junjie YangBeijing Key Laboratory of Gene Resource and Molecular Development, Laboratory of Neuroscience and Brain Development, Beijing Normal University, Beijing, 100875, China.
Yaxin WangBeijing Key Laboratory of Gene Resource and Molecular Development, Laboratory of Neuroscience and Brain Development, Beijing Normal University, Beijing, 100875, China.
Yingyu SunBeijing Key Laboratory of Gene Resource and Molecular Development, Laboratory of Neuroscience and Brain Development, Beijing Normal University, Beijing, 100875, China.
Fuchou TangBiodynamic Optical Imaging Center (BIOPIC), School of Life Sciences, Peking University, Beijing, 100871, China.
Xiaodong SuBiodynamic Optical Imaging Center (BIOPIC), School of Life Sciences, Peking University, Beijing, 100871, China.
Chuan FangDepartment of Neurosurgery, Affiliated Hospital of Hebei University, Baoding, 071000, China. chuanfang@hbu.edu.cn.
Tao JiangBeijing Neurosurgical Institute, Beijing, 100070, China. taojiang1964@163.com.
Xiaolong FanBeijing Key Laboratory of Gene Resource and Molecular Development, Laboratory of Neuroscience and Brain Development, Beijing Normal University, Beijing, 100875, China. xfan@bnu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Detailed characterizations of genomic alterations have not identified subtype-specific vulnerabilities in adult gliomas. Mapping gliomas into developmental programs may uncover new vulnerabilities that are not strictly related to genomic alterations. After identifying conserved gene modules co-expressed with EGFR or PDGFRA (EM or PM), we recently proposed an EM/PM classification scheme for adult gliomas in a histological subtype- and grade-independent manner. By using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same glioma, single-cell RNA-seq samples, and clinical samples, we here demonstrate the temporal and spatial stability of the EM and PM subtypes. The EM and PM subtypes, which progress in a subtype-specific mode, are robustly maintained in paired longitudinal samples. Elevated activities of cell proliferation, genomic instability and microenvironment, rather than subtype switching, mark recurrent gliomas. Within individual gliomas, the EM/PM subtype was preserved across regions and single cells. Malignant cells in the EM and PM gliomas were correlated to neural stem cell and oligodendrocyte progenitor cell compartment, respectively. Thus, while genetic makeup may change during progression and/or within different tumor areas, adult gliomas evolve within a neurodevelopmental framework of the EM and PM molecular subtypes. The dysregulated developmental pathways embedded in these molecular subtypes may contain subtype-specific vulnerabilities.

Indexed as

Brain NeoplasmsGliomaNeural Stem CellsOligodendrocyte Precursor CellsHumansNeoplasm Recurrence, LocalTumor MicroenvironmentEM/PM subtypingglioma progressionintratumor heterogeneitymolecular classification

Identifiers

PMID36645634

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.