Evidence map›Paper›PMID 36647244›Full record

Trial reportOrthopaedic surgery2023

Clinical Efficacy of Intra-Articular Injection with P-PRP Versus that of L-PRP in Treating Knee Cartilage Lesion: A Randomized Controlled Trial.

Yiqin Zhou, Haobo Li, Shiqi Cao, Yaguang Han, Jiahua Shao, Qiwei Fu, Bo Wang, Jun Wu, Dong Xiang, Ziye Liu and 5 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Orthopaedic surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Yiqin ZhouDepartment of Radiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID https://orcid.org/0000-0001-6479-4020
Haobo LiDepartment of Orthopedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0000-0002-1234-4412
Shiqi CaoDepartment of Orthopaedics, Chinese PLA General Hospital, Beijing, China.
Yaguang HanDepartment of Orthopedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0000-0003-3861-3358
Jiahua ShaoDepartment of Orthopedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0000-0002-7324-1812
Qiwei FuDepartment of Orthopedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0000-0003-3775-8248
Bo WangDepartment of Orthopedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.
Jun WuDepartment of Orthopedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0000-0003-2024-0792
Dong XiangDepartment of Orthopedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.
Ziye LiuDepartment of Orthopedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.
Huang WangDepartment of Orthopedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.
Jun ZhuDepartment of Orthopedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0000-0002-0859-3483
Qirong QianDepartment of Orthopedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0000-0002-6867-1666
Xiaolei YangDepartment of Anesthesiology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.
Song WangDepartment of Radiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Shanghai Changzheng Hospital · CNShanghai University of Traditional Chinese Medicine · CNChinese PLA General Hospital · CN

Funding

Chinese PLA General Hospital CXPY201812Chinese PLA General Hospital QNF19009National Natural Science Foundation of China 81972087
6 · The paper itself

Abstract

objectivePlatelet-rich plasma（PRP), with different concentration of leukocytes, may lead to varying effects in the treatment of cartilage lesions. So far, current research has not shown enough evidence on this. To evaluate the clinical efficacy and safety of intra-articular injection with pure platelet-rich plasma (P-PRP) versus those of leukocyte platelet-rich plasma (L-PRP) in treating knee cartilage lesions, we conducted a double-blind, randomized controlled clinical trial with a larger sample and longer follow-up period.

methodsFrom October 2019 to October 2020, 95 patients were invited to participate in our study, and 60 (63.2%) were randomized to P-PRP (n = 30) or L-PRP (n = 30) groups. Patients from the two groups were treated with knee intra-articular injections of P-PRP or L-PRP. Visual analog scale (VAS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores were assessed using an unpaired t-test for independent samples preoperatively and at 6 weeks, 12 weeks, 6 months, and 12 months after intervention.

resultsWe followed up 27 cases in the P-PRP group and 26 cases in the L-PRP group. No significant differences in VAS and WOMAC scores were found between the two groups before the intervention (p > 0.05). The WOMAC Pain and VAS-Motions scores of the P-PRP group were significantly lower than those of the L-PRP group at 6 weeks after the intervention (p < 0.05). While the long-term clinical efficacy of both injections was similar and weakened after 12 months, more adverse events were found in the L-PRP group.

conclusionsThe short-term results demonstrate a positive effect in reducing pain and improving function in patients with knee cartilage lesions in the two groups. While the P-PRP injection showed better clinical efficacy in the early phase of postoperative rehabilitation and resulted in fewer adverse events, long-term follow-up showed similar and weakened efficacy after 12 months.

trial registrationChiCTR1900026365. Registered on October 3, 2019, http://www.chictr.org.cn/showproj.aspx?proj=43911.

Indexed as

Osteoarthritis, KneePlatelet-Rich PlasmaHumansHyaluronic AcidInjections, Intra-ArticularPainTreatment OutcomeHyaluronic AcidCartilage regenerationKnee cartilage lesionL-PRPP-PRPRandomized controlled trial

Identifiers

PMID36647244
PMCPMC9977604
OpenAlexW4316927726

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.