Evidence map›Paper›PMID 36650367›Full record

ReviewStem cell reviews and reports2023

Immunomodulatory and Anti-inflammatory effect of Neural Stem/Progenitor Cells in the Central Nervous System.

Wei Ni, Murugan Ramalingam, Yumeng Li, Jeong-Hui Park, Khandmaa Dashnyam, Jung-Hwan Lee, Nora Bloise, Lorenzo Fassina, Livia Visai, Maria Gabriella Cusella De Angelis and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Stem cell reviews and reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. "Time Is Brain" - for Cell Therapies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 4 countries.

Wei Ni *Department of Clinical Laboratory, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou, 213000, Jiangsu, China.
Murugan Ramalingam *Institute of Tissue Regeneration Engineering, Dankook University, Cheonan, 31116, Republic of Korea. rmurug2000@gmail.com.
Yumeng LiInstitute of Tissue Regeneration Engineering, Dankook University, Cheonan, 31116, Republic of Korea.
Jeong-Hui ParkInstitute of Tissue Regeneration Engineering, Dankook University, Cheonan, 31116, Republic of Korea.
Khandmaa DashnyamInstitute of Tissue Regeneration Engineering, Dankook University, Cheonan, 31116, Republic of Korea.
Jung-Hwan LeeInstitute of Tissue Regeneration Engineering, Dankook University, Cheonan, 31116, Republic of Korea.
Nora BloiseDepartment of Molecular Medicine, Centre for Health Technologies (CHT), INSTM UdR of Pavia, University of Pavia, 27100, Pavia, Italy.
Lorenzo FassinaDepartment of Electrical, Computer and Biomedical Engineering, University of Pavia, 27100, Pavia, Italy.
Livia VisaiDepartment of Molecular Medicine, Centre for Health Technologies (CHT), INSTM UdR of Pavia, University of Pavia, 27100, Pavia, Italy.
Maria Gabriella Cusella De AngelisDepartment of Public Health, Experimental and Forensic Medicine, Human Anatomy Unit, University of Pavia, 27100, Pavia, Italy.
Jose Luis PedrazNanoBioCel Research Group, Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country (UPV/EHU), 01006, Vitoria-Gasteiz, Spain.
Hae-Won KimInstitute of Tissue Regeneration Engineering, Dankook University, Cheonan, 31116, Republic of Korea. kimhw@dku.edu.
Jiabo HuJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, 212013, Jiangsu, China. hu@ujs.edu.cn.ORCID 0000-0003-1974-984X
Dankook University · KRUniversity of Pavia · ITJiangsu University · CNChengdu Medical College · CNUniversity of the Basque Country · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroinflammation is a critical event that responds to disturbed homeostasis and governs various neurological diseases in the central nervous system (CNS). The excessive inflammatory microenvironment in the CNS can adversely affect endogenous neural stem cells, thereby impeding neural self-repair. Therapies with neural stem/progenitor cells (NSPCs) have shown significant inhibitory effects on inflammation, which is mainly achieved through intercellular contact and paracrine signalings. The intercellular contact between NSPCs and immune cells, the activated CNS- resident microglia, and astrocyte plays a critical role in the therapeutic NSPCs homing and immunomodulatory effects. Moreover, the paracrine effect mainly regulates infiltrating innate and adaptive immune cells, activated microglia, and astrocyte through the secretion of bioactive molecules and extracellular vesicles. However, the molecular mechanism involved in the immunomodulatory effect of NSPCs is not well discussed. This article provides a systematic analysis of the immunomodulatory mechanism of NSPCs, discusses efficient ways to enhance its immunomodulatory ability, and gives suggestions on clinical therapy.

Indexed as

Neural Stem CellsAnti-Inflammatory AgentsAstrocytesCentral Nervous SystemHumansInflammationAnti-Inflammatory Agentsextracellular vesiclesGenetic engineeringimmune cellsimmunomodulationNeural stem/progenitor cellsneuroinflammation

Identifiers

PMID36650367
OpenAlexW4316927818

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.