Evidence map›Paper›PMID 36653210›Full record

SynthesisBiological psychiatry. Cognitive neuroscience and neuroimaging2023

Combined Cognitive Training and Transcranial Direct Current Stimulation in Neuropsychiatric Disorders: A Systematic Review and Meta-analysis.

Cynthia Z Burton, Emily O Garnett, Emily Capellari, Soo-Eun Chang, Ivy F Tso, Benjamin M Hampstead, Stephan F Taylor

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 6 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 6 syntheses or guidelines pooled it, 48 citations in OpenAlex.

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  18. Use of physical activity by occupational therapists and speech-language therapists in KwaZulu-Natal.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Cynthia Z BurtonDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan. Electronic address: czburton@med.umich.edu.
Emily O GarnettDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan.
Emily CapellariTaubman Health Sciences Library, University of Michigan, Ann Arbor, Michigan.
Soo-Eun ChangDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan.
Ivy F TsoDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan.
Benjamin M HampsteadDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan; Mental Health Service, U.S. Department of Veterans Affairs, VA Ann Arbor Healthcare System, Ann Arbor, Michigan.
Stephan F TaylorDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan.
University of Michigan · USVA Ann Arbor Healthcare System · US

Funding

Research Program on Cognition and Neuromodulation Based Interventions (RP-CNBI)R35AG072262 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAMPSTEAD, BENJAMIN MICHAEL · 2021 to 2025
$4.2M
NIA NIH HHS R35 AG072262
6 · The paper itself

Abstract

backgroundTreatments for cognitive dysfunction in neuropsychiatric conditions are urgently needed. Cognitive training and transcranial direct current stimulation (tDCS) hold promise, and there is growing interest in combined or multimodal treatments, though studies to date have had small samples and inconsistent results.

methodsA systematic review and meta-analysis was completed. Retained studies included cognitive training combined with active or sham tDCS in a neuropsychiatric population and reported a posttreatment cognitive outcome. Meta-analyses included effect sizes comparing cognitive training plus active tDCS and cognitive training plus sham tDCS in 5 cognitive domains. Risk of bias in included studies and across studies was explored.

resultsFifteen studies were included: 10 in neurodegenerative disorders and 5 in psychiatric disorders (n = 629). There were several tDCS montages, though two-thirds of studies placed the anode over the left dorsolateral prefrontal cortex. A wide variety of cognitive training types and outcome measures were reported. There was a small, statistically significant effect of combined treatment on measures of attention/working memory, as well as small and non-statistically significant effects favoring combined treatment on global cognition and language. There was no evidence of bias in individual studies but some evidence of nonreporting or small-study bias across studies.

conclusionsThese results may provide preliminary support for the efficacy of combined cognitive training and tDCS on measures of attention/working memory. More data are needed, particularly via studies that explicitly align the cognitive ability of interest, stimulation target, training type, and outcome measures.

Indexed as

Transcranial Direct Current StimulationCognitionCognitive TrainingHumansMemory, Short-TermPrefrontal CortexBrain stimulationCognitionCognitive rehabilitationDementiaNeuromodulationSchizophrenia

Identifiers

PMID36653210
PMCPMC10823589
OpenAlexW4304893634

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.