Evidence map›Paper›PMID 36653531›Full record

ReviewNature reviews. Neuroscience2023

Development, wiring and function of dopamine neuron subtypes.

Oxana Garritsen, Eljo Y van Battum, Laurens M Grossouw, R Jeroen Pasterkamp

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. System-level synchronization and subtype-specific modules govern brain-wide serotonin axon innervation.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  13. Combination antiviral and anti-inflammatory therapy mitigates persistent neurological deficits in mice post SARS-CoV-2 infection.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  14. Neuroprotective role of bilirubin in Parkinson's disease.Frontiers in aging neuroscience · 2026
    Review
  15. Review
  16. Merkel cell mechanotransduction facilitates adult neurogenesis and cognition in an enriched environment.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Oxana Garritsen *Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center, Utrecht University, Utrecht, Netherlands.ORCID 0000-0002-4646-5474
Eljo Y van Battum *Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center, Utrecht University, Utrecht, Netherlands.
Laurens M Grossouw *Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center, Utrecht University, Utrecht, Netherlands.
R Jeroen PasterkampDepartment of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center, Utrecht University, Utrecht, Netherlands. r.j.pasterkamp@umcutrecht.nl.ORCID 0000-0003-1631-6440
Utrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct neuron subtypes that mediate specific behaviours and are linked to various brain diseases. Considerable progress has been made in identifying mDA neuron subtypes, and recent work has begun to unveil how these neuronal subtypes develop and organize into functional brain structures. This progress is important for further understanding the disparate physiological functions of mDA neurons and their selective vulnerability in disease, and will ultimately accelerate therapy development. This Review discusses recent advances in our understanding of molecularly defined mDA neuron subtypes and their circuits, ranging from early developmental events, such as neuron migration and axon guidance, to their wiring and function, and future implications for therapeutic strategies.

Indexed as

Brain DiseasesDopaminergic NeuronsBrainDopamineHumansMesencephalonDopamine

Identifiers

PMID36653531
OpenAlexW4317234536

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.