Evidence map›Paper›PMID 36654800›Full record

ArticleMolecular therapy. Methods & clinical development2023

Molecular homing and retention of muscle membrane stabilizing copolymers by non-invasive optical imaging in vivo.

Addeli Bez Batti Angulski, Houda Cohen, Mihee Kim, Dongwoo Hahn, Nicholas Van Zee, Timothy P Lodge, Marc A Hillmyer, Benjamin J Hackel, Frank S Bates, Joseph M Metzger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Synthetic bottlebrush block copolymer prevents disease onset in Duchenne muscular dystrophy.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Discovery of Kinetic Trapping of Poloxamers inside Liposomes via Thermal Treatment.Langmuir : the ACS journal of surfaces and colloids · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Addeli Bez Batti AngulskiDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, 6-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA.
Houda CohenDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, 6-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA.
Mihee KimDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA.
Dongwoo HahnDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, 6-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA.
Nicholas Van ZeeDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA.
Timothy P LodgeDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA.
Marc A HillmyerDepartment of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Benjamin J HackelDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA.
Frank S BatesDepartment of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA.
Joseph M MetzgerDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, 6-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA.
University of Minnesota · US

Funding

Targeted membrane integrity in cardiac ischemia and reperfusionR01HL122323 · NHLBI · UNIVERSITY OF MINNESOTA · PI METZGER, JOSEPH MARK · 2015 to 2022
$5.1M
Copolymer-Based Sarcolemma Stabilization for Protecting Dystrophic Skeletal Muscles in VivoR01AR071349 · NIAMS · UNIVERSITY OF MINNESOTA · PI METZGER, JOSEPH MARK · 2018 to 2022
$2.3M
NHLBI NIH HHS R01 HL122323NIAMS NIH HHS R01 AR071349
6 · The paper itself

Abstract

First-in-class membrane stabilizer Poloxamer 188 (P188) has been shown to confer membrane protection in an extensive range of clinical conditions; however, elements of the systemic distribution and localization of P188 at the organ, tissue, and muscle fiber levels

Indexed as

biodistributioncopolymer-membrane associationdamaged muscle membraneDuchenne muscular dystrophydystrophin-deficient mdx micemembrane stabilizerPoloxamer 188synthetic block copolymers

Identifiers

PMID36654800
PMCPMC9829555
OpenAlexW4310927947

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.