Evidence map›Paper›PMID 36658081›Full record

ArticleNeurobiology of aging2023

Genome-wide association study of executive function in a multi-ethnic cohort implicates LINC01362: Results from the northern Manhattan study.

Nicole Dueker, Liyong Wang, Hannah Gardener, Lissette Gomez, Sonya Kaur, Ashley Beecham, Susan H Blanton, Chuanhui Dong, Jose Gutierrez, Ying Kuen Cheung and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Nicole DuekerJohn P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA. Electronic address: ndueker@med.miami.edu.
Liyong WangJohn P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA; Dr. John T. Macdonald, Department of Human Genetics, University of Miami, Miami, FL USA.
Hannah GardenerDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, FL USA.
Lissette GomezJohn P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
Sonya KaurDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, FL USA; Department of Neurology, Evelyn F. McKnight Brain Institute, University of Miami, Miami FL USA.
Ashley BeechamJohn P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
Susan H BlantonJohn P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA; Dr. John T. Macdonald, Department of Human Genetics, University of Miami, Miami, FL USA.
Chuanhui DongDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, FL USA.
Jose GutierrezDepartment of Neurology and the Gertrude H Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY USA.
Ying Kuen CheungDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA.
Yeseon P MoonDepartment of Neurology and the Gertrude H Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY USA.
Bonnie LevinDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, FL USA; Department of Neurology, Evelyn F. McKnight Brain Institute, University of Miami, Miami FL USA.
Clinton B WrightNational Institute of Neurological Disorders and Stroke, Bethesda, MD USA.
Mitchell S V ElkindDepartment of Neurology and the Gertrude H Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY USA.
Ralph L SaccoDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, FL USA; Department of Neurology, Evelyn F. McKnight Brain Institute, University of Miami, Miami FL USA; Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL USA.
Tatjana RundekDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, FL USA; Department of Neurology, Evelyn F. McKnight Brain Institute, University of Miami, Miami FL USA; Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL USA.
University of Miami · USColumbia University · USDr. John T. Macdonald Foundation · USNational Institute of Neurological Disorders and Stroke · US

Funding

STROKE INCIDENCE AND RISK FACTORS IN A TRI-ETHNIC REGIONR01NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 1993 to 2019
$19.2M
Vascular Determinants of Dementia and Cognitive Decline in a Tri-Ethnic RegionR56NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, RUNDEK, TATJANA · 2021 to 2021
$537k
NINDS NIH HHS R01 NS029993NINDS NIH HHS R56 NS029993
6 · The paper itself

Abstract

Executive function is a cognitive domain with sizable heritability representing higher-order cognitive abilities. Genome-wide association studies (GWAS) of executive function are sparse, particularly in populations underrepresented in medical research. We performed a GWAS on a composite measure of executive function that included measures of mental flexibility and reasoning using data from the Northern Manhattan Study, a racially and ethnically diverse cohort (N = 1077, 69% Hispanic, 17% non-Hispanic Black and 14% non-Hispanic White). Four SNPs located in the long intergenic non-protein coding RNA 1362 gene, LINC01362, on chromosome 1p31.1, were significantly associated with the composite measure of executive function in this cohort (top SNP rs2788328, ß = 0.22, p = 3.1 × 10

Indexed as

Executive FunctionGenome-Wide Association StudyBlack or African AmericanBrainCognitionHispanic or LatinoHumansPolymorphism, Single NucleotideCognitionExecutive functionGenetic associationGWASMinority populations

Identifiers

PMID36658081
PMCPMC10064578
OpenAlexW4310732270

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.