Evidence map›Paper›PMID 36658771›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction.

Wenyan Xie, Xi Wei, Heemin Kang, Hong Jiang, Zhiqin Chu, Yuan Lin, Yong Hou, Qiang Wei

Full text readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed.

  1. Article
  2. Review
  3. Liquid-Responsive Shape-Memory Nanofiber-Reinforced Scaffolds for Cartilage Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenyan XieDepartment of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610065, China.
Xi WeiDepartment of Mechanical Engineering, The University of Hong Kong, Hong Kong, China.
Heemin KangDepartment of Materials Science and Engineering, Korea University, Seoul, 02841, South Korea.
Hong JiangDepartment of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610065, China.
Zhiqin ChuDepartment of Electrical and Electronic Engineering (Joint Appointment with School of Biomedical Sciences), The University of Hong Kong, Hong Kong, China.
Yuan LinDepartment of Mechanical Engineering, The University of Hong Kong, Hong Kong, China.
Yong HouDepartment of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China.ORCID 0000-0001-6898-3216
Qiang WeiCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials and Engineering, Sichuan University, Chengdu, 610065, China.

Funding

China Scholarship CouncilNational Natural Science Foundation of China 32000951National Natural Science Foundation of China 51973129
6 · The paper itself

Abstract

The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical, biological, and chemical signals to embraced cells. Increasing evidence suggests that mechanical signals derived from the dynamic cellular microenvironment are essential controllers of cell behaviors. Conventional cell culture biomaterials, with static mechanical properties such as chemistry, topography, and stiffness, have offered a fundamental understanding of various vital biochemical and biophysical processes, such as cell adhesion, spreading, migration, growth, and differentiation. At present, novel biomaterials that can spatiotemporally impart biophysical cues to manipulate cell fate are emerging. The dynamic properties and adaptive traits of new materials endow them with the ability to adapt to cell requirements and enhance cell functions. In this review, an introductory overview of the key players essential to mechanobiology is provided. A biophysical perspective on the state-of-the-art manipulation techniques and novel materials in designing static and dynamic ECM-mimicking biomaterials is taken. In particular, different static and dynamic mechanical cues in regulating cellular mechanosensing and functions are compared. This review to benefit the development of engineering biomechanical systems regulating cell functions is expected.

Indexed as

Biocompatible MaterialsMechanotransduction, CellularCell AdhesionCell Culture TechniquesExtracellular MatrixBiocompatible Materialscellular forceECM dynamicsengineering biomaterialsmatrix mechanicsmechanotransduction

Identifiers

PMID36658771
PMCPMC10037983

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read61
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.