ReviewAnnals of translational medicine2022
Benefits and risks of essential trace elements in chronic kidney disease: a narrative review.
Review in Annals of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07109778 (Impact of Copper to Zinc Ratio on Outcome of End Stage Renal Disease Patients), which is not on this map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Copper to Zinc Ratio on Outcome of End Stage Renal Disease Patients
Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Association Between Whole Blood Rubidium Levels and Anemia in Maintenance Hemodialysis Patients: A Multicenter Cross-Sectional Study.Biological trace element research · 2026Article
- Hyperbaric Oxygen Therapy - a Potential Therapy for Macro- and Trace Elements' Imbalance in Patients with Chronic Kidney Disease?Biological trace element research · 2026Article
- Essential Trace Elements in Commonly Consumed Varieties of Sri Lankan Cooked Rice and its Dietary Significance: A Focus on Recommended Daily Allowances.Biological trace element research · 2026Article
- Trace Element Imbalance and Redox-Relevant Serum Profile in Hemodialysis: A Validated Multielement ICP-MS Study.Antioxidants (Basel, Switzerland) · 2026Article
- Evaluation of the Relationship Between Trace Element Levels and Cellular Adhesion Molecules (ICAM-1, VCAM-1) in Hemodialysis Patients.Journal of clinical medicine · 2026Article
- Nutrient intake and renal cancer: molecular pathways and mechanistic insights into the protective role of dietary components.Frontiers in nutrition · 2026Review
- Urinary heavy metal and trace element mixtures in chronic kidney disease: associations and implications for potential reverse causality.Frontiers in toxicology · 2026Article
- Non-linear associations between serum manganese with chronic kidney disease: results from two nationwide studies in the United States and China.Renal failure · 2025Article
- Bulk and single-cell transcriptomics of stomach adenocarcinoma provide prognostic insights via the application of a novel gene signature associated with manganese metabolism.Translational cancer research · 2025Article
- The impact of nano zinc on broiler productivity, tibia bone characteristics, and gut microbiota.Scientific reports · 2025Article
- A manganese metabolism-related gene signature stratifies prognosis and immunotherapy efficacy in kidney cancer.Discover oncology · 2025Article
- Zinc Deficiency in Chronic Kidney Disease and Hemodialysis: Insights from Basic Research to Clinical Implications.Nutrients · 2025Review
- Combined Effect of per- and Polyfluoroalkyl Substances, Toxic Metals, and Essential Elements on Chronic Kidney Disease.Pollutants · 2025Article
- Impact of dietary supplementation with biological zinc, selenium nanoparticles, and their combination on growth, carcass characteristics, blood parameters, and meat quality in broiler chickens.Journal of advanced veterinary and animal research · 2025Article
- The effects of developmental cadmium exposure on health and disease.Disease models & mechanisms · 2025Review
- Serum Metallome Features and Their Effects on Chronic Kidney Disease: A Comparative Study.International journal of general medicine · 2025Article
- The relationship between copper intake and chronic kidney disease/diabetic kidney disease: insights from NHANES data (2011-2018).Frontiers in endocrinology · 2025Article
- Role of urinary trace elements in diabetic kidney disease: a cross-sectional analysis.BMJ open diabetes research & care · 2024Article
- Evaluation of lipid profile, liver function enzymes, and trace elements in Iraqi diabetic nephropathy patients.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Article
- Associations between serum mineral concentrations and mortality by renal function in the Ludwigshafen Risk and Cardiovascular Health Study.Scientific reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objective: Chronic kidney disease (CKD) is an important public health concern. With the decline of renal function, CKD patients gradually progress to end-stage kidney disease and need to undergo dialysis or kidney transplantation to maintain life, bringing a heavy economic burden to the family and society. Therefore, it is necessary to effectively prevent and delay the progression of CKD. Essential trace elements play an indispensable role in CKD, and the objective of this study is to systematically review their benefits in the disease and summarize the risks of their excess. Methods: The keywords "trace elements", "chronic kidney disease", "dialysis", "inflammation", and "fibrosis" and their combinations were used to search for relevant literature published in the PubMed database and Web of Science. We then summarized the role of trace element abnormalities in CKD patients in anemia, oxidative stress, inflammation, and chronic fibrosis, and the risk of their excess. Key Content and Findings: Imbalance of essential trace elements is a common complication of CKD and a risk factor for CKD progression, cardiovascular events, and death. This article reviews the effects of essential trace elements (iron, zinc, selenium, copper, iodine, and manganese) on CKD. We analyze literature and discuss the advantages and disadvantages of various essential trace elements. Conclusions: Research shows CKD patients have an imbalance of essential trace elements, and treatment based on these is an important direction for future exploration. A knowledge of the homeostasis of trace elements is important to improving the prognosis of CKD patients and delaying the progression of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.