Evidence map›Paper›PMID 36662411›Full record

ArticleNeurotoxicity research2023

α-Synuclein-Induced Destabilized BMAL1 mRNA Leads to Circadian Rhythm Disruption in Parkinson's Disease.

Jun-Yi Liu, Jian Xue, Fen Wang, Ya-Li Wang, Wan-Li Dong

Abstract read
PubMed Publisher
In one paragraph

Article in Neurotoxicity research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jun-Yi LiuDepartment of Neurology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, 214123, China.
Jian XueDepartment of Neurology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, 214123, China.
Fen WangInstitute of Neuroscience, Soochow University, Suzhou, 215123, China.
Ya-Li WangDepartment of Neurology, Suzhou Municipal Hospital (North), Nanjing Medical University, Suzhou, 215008, China. yjyali@sina.com.
Wan-Li DongDepartment of Neurology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, 214123, China. dwlsz8@163.com.
Soochow University · CNSuzhou Municipal Hospital · CN

Funding

GuSu District Health Talent Training Project GSWS2020076National Natural Science Foundation of China 81801253Natural Science Foundation of Jiangsu Province BK20180214
6 · The paper itself

Abstract

Circadian dysfunction is a common non-motor symptom in Parkinson's disease (PD). The potential influence of aggravated α-synuclein (SNCA) on circadian disruption remains unclear. SNCA

Indexed as

MicroRNAsParkinson Diseasealpha-SynucleinAnimalsARNTL Transcription FactorsBrainCircadian RhythmMiceMice, TransgenicMusclesRatsalpha-SynucleinARNTL Transcription FactorsMicroRNAsMIRN155 microRNA, ratBMAL1Circadian dysfunctionParkinson’s diseaseα-Synuclein

Identifiers

PMID36662411
OpenAlexW4317568082

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.