Evidence map›Paper›PMID 36669875›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2023

Pharmacologic Activity of Substituted Tryptamines at 5-Hydroxytryptamine (5-HT)

Laura B Kozell, Amy J Eshleman, Tracy L Swanson, Shelley H Bloom, Katherine M Wolfrum, Jennifer L Schmachtenberg, Randall J Olson, Aaron Janowsky, Atheir I Abbas

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Drug-drug interactions involving classic psychedelics: A systematic review.Journal of psychopharmacology (Oxford, England) · 2024
    Pooled it
  3. Article
  4. Review
  5. Article
  6. ACS omega · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
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  15. Review
  16. Article
  17. Article
  18. Article
  19. The Human Microbiome-A Physiologic Perspective.Comprehensive Physiology · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Laura B KozellVeterans Affairs Portland Health Care System (L.B.K., A.J.E., T.L.S., S.H.B., K.M.W., J.L.S., A.J., A.I.A.) and Departments of Psychiatry (L.B.K., A.J.E., T.L.S., A.J., A.I.A.) and Behavioral Neuroscience (L.B.K., R.J.O., A.I.A.), Oregon Health & Science University, Portland, Oregon.
Amy J EshlemanVeterans Affairs Portland Health Care System (L.B.K., A.J.E., T.L.S., S.H.B., K.M.W., J.L.S., A.J., A.I.A.) and Departments of Psychiatry (L.B.K., A.J.E., T.L.S., A.J., A.I.A.) and Behavioral Neuroscience (L.B.K., R.J.O., A.I.A.), Oregon Health & Science University, Portland, Oregon.
Tracy L SwansonVeterans Affairs Portland Health Care System (L.B.K., A.J.E., T.L.S., S.H.B., K.M.W., J.L.S., A.J., A.I.A.) and Departments of Psychiatry (L.B.K., A.J.E., T.L.S., A.J., A.I.A.) and Behavioral Neuroscience (L.B.K., R.J.O., A.I.A.), Oregon Health & Science University, Portland, Oregon.
Shelley H BloomVeterans Affairs Portland Health Care System (L.B.K., A.J.E., T.L.S., S.H.B., K.M.W., J.L.S., A.J., A.I.A.) and Departments of Psychiatry (L.B.K., A.J.E., T.L.S., A.J., A.I.A.) and Behavioral Neuroscience (L.B.K., R.J.O., A.I.A.), Oregon Health & Science University, Portland, Oregon.
Katherine M WolfrumVeterans Affairs Portland Health Care System (L.B.K., A.J.E., T.L.S., S.H.B., K.M.W., J.L.S., A.J., A.I.A.) and Departments of Psychiatry (L.B.K., A.J.E., T.L.S., A.J., A.I.A.) and Behavioral Neuroscience (L.B.K., R.J.O., A.I.A.), Oregon Health & Science University, Portland, Oregon.
Jennifer L SchmachtenbergVeterans Affairs Portland Health Care System (L.B.K., A.J.E., T.L.S., S.H.B., K.M.W., J.L.S., A.J., A.I.A.) and Departments of Psychiatry (L.B.K., A.J.E., T.L.S., A.J., A.I.A.) and Behavioral Neuroscience (L.B.K., R.J.O., A.I.A.), Oregon Health & Science University, Portland, Oregon.
Randall J OlsonVeterans Affairs Portland Health Care System (L.B.K., A.J.E., T.L.S., S.H.B., K.M.W., J.L.S., A.J., A.I.A.) and Departments of Psychiatry (L.B.K., A.J.E., T.L.S., A.J., A.I.A.) and Behavioral Neuroscience (L.B.K., R.J.O., A.I.A.), Oregon Health & Science University, Portland, Oregon.
Aaron JanowskyVeterans Affairs Portland Health Care System (L.B.K., A.J.E., T.L.S., S.H.B., K.M.W., J.L.S., A.J., A.I.A.) and Departments of Psychiatry (L.B.K., A.J.E., T.L.S., A.J., A.I.A.) and Behavioral Neuroscience (L.B.K., R.J.O., A.I.A.), Oregon Health & Science University, Portland, Oregon.
Atheir I AbbasVeterans Affairs Portland Health Care System (L.B.K., A.J.E., T.L.S., S.H.B., K.M.W., J.L.S., A.J., A.I.A.) and Departments of Psychiatry (L.B.K., A.J.E., T.L.S., A.J., A.I.A.) and Behavioral Neuroscience (L.B.K., R.J.O., A.I.A.), Oregon Health & Science University, Portland, Oregon abbasat@ohsu.edu.ORCID 0000-0002-7080-3509
Oregon Health & Science University · US

Funding

BIOLOGICAL BASES OF DRUG-SEEKING BEHAVIORT32DA007262 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 1991 to 2022
$9.4M
NIDA NIH HHS T32 DA007262
6 · The paper itself

Abstract

Novel psychoactive substances, including synthetic substituted tryptamines, represent a potential public health threat. Additionally, some substituted tryptamines are being studied under medical guidance as potential treatments of psychiatric disorders. Characterizing the basic pharmacology of substituted tryptamines will aid in understanding differences in potential for harm or therapeutic use. Using human embryonic kidney cells stably expressing 5-hydroxytryptamine (5-HT)

Indexed as

HallucinogensTryptaminesHumansReceptor, Serotonin, 5-HT2AReceptor, Serotonin, 5-HT2CSerotoninSerotonin Plasma Membrane Transport ProteinsHallucinogensReceptor, Serotonin, 5-HT2AReceptor, Serotonin, 5-HT2CSerotoninSerotonin Plasma Membrane Transport ProteinsTryptamines

Identifiers

PMID36669875
PMCPMC10029822
OpenAlexW4317600184

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.