Evidence map›Paper›PMID 36670960›Full record

ArticleAntioxidants (Basel, Switzerland)2022

An SPM-Enriched Marine Oil Supplement Shifted Microglia Polarization toward M2, Ameliorating Retinal Degeneration in

Lorena Olivares-González, Sheyla Velasco, Idoia Gallego, Marina Esteban-Medina, Gustavo Puras, Carlos Loucera, Alicia Martínez-Romero, María Peña-Chilet, José Luis Pedraz, Regina Rodrigo

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. drexml: A command line tool and Python package for drug repurposing.Computational and structural biotechnology journal · 2024
    Article
  2. Article
  3. Article
  4. Role of microglia/macrophage polarisation in intraocular diseases (Review).International journal of molecular medicine · 2024
    Review
  5. Article
  6. Bifunctional MXene-Augmented Retinal Progenitor Cell Transplantation for Retinal Degeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lorena Olivares-GonzálezGroup of Pathophysiology and Therapies for Vision Disorders, Príncipe Felipe Research Center (CIPF), 46012 Valencia, Spain.ORCID 0000-0001-8180-1229
Sheyla VelascoGroup of Pathophysiology and Therapies for Vision Disorders, Príncipe Felipe Research Center (CIPF), 46012 Valencia, Spain.ORCID 0000-0002-4242-7112
Idoia GallegoNanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), 01006 Vitoria-Gasteiz, Spain.ORCID 0000-0002-9312-8147
Marina Esteban-MedinaComputational Medicine Platform, Andalusian Public Foundation Progress and Health-FPS Hospital Virgen del Rocío, 41013 Seville, Spain.ORCID 0000-0003-2632-9587
Gustavo PurasNanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), 01006 Vitoria-Gasteiz, Spain.ORCID 0000-0002-1536-7601
Carlos LouceraComputational Medicine Platform, Andalusian Public Foundation Progress and Health-FPS Hospital Virgen del Rocío, 41013 Seville, Spain.ORCID 0000-0001-9598-6965
Alicia Martínez-RomeroCytomic Unit, Príncipe Felipe Research Center (CIPF), 46012 Valencia, Spain.ORCID 0000-0002-5197-0635
María Peña-ChiletComputational Medicine Platform, Andalusian Public Foundation Progress and Health-FPS Hospital Virgen del Rocío, 41013 Seville, Spain.ORCID 0000-0002-6445-9617
José Luis PedrazNanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), 01006 Vitoria-Gasteiz, Spain.ORCID 0000-0002-3938-2267
Regina RodrigoGroup of Pathophysiology and Therapies for Vision Disorders, Príncipe Felipe Research Center (CIPF), 46012 Valencia, Spain.ORCID 0000-0001-5875-986X

Funding

Centre for Biomedical Network Research on Rare Diseases ACCI 2018Instituto de Salud Carlos III PI18/00252Instituto de Salud Carlos III PI20/01305Regional Government of Andalusia PAIDI2020- DOC_00350Regional Government of Andalusia PE-0002-2018RETINA COMUNIDAD VALENCIANA RETINACV_RODRIGO 2022
6 · The paper itself

Abstract

Retinitis pigmentosa (RP) is the most common inherited retinal dystrophy causing progressive vision loss. It is accompanied by chronic and sustained inflammation, including M1 microglia activation. This study evaluated the effect of an essential fatty acid (EFA) supplement containing specialized pro-resolving mediators (SPMs), on retinal degeneration and microglia activation in

Indexed as

inflammationinherited retinal dystrophiesmicrogliaoxidative stressretinitis pigmentosaspecialized pro-resolving mediators

Identifiers

PMID36670960
PMCPMC9855087

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.