Evidence map›Paper›PMID 36672439›Full record

ArticleCancers2023

Libertellenone T, a Novel Compound Isolated from Endolichenic Fungus, Induces G2/M Phase Arrest, Apoptosis, and Autophagy by Activating the ROS/JNK Pathway in Colorectal Cancer Cells.

Chathurika D B Gamage, Jeong-Hyeon Kim, Yi Yang, İsa Taş, So-Yeon Park, Rui Zhou, Sultan Pulat, Mücahit Varlı, Jae-Seoun Hur, Sang-Jip Nam and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. 7,7-Bis(3-Indolyl)-Journal of microbiology and biotechnology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Chathurika D B GamageCollege of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, 255 Jungang-ro, Sunchon, Jeonnam 57922, Republic of Korea.ORCID 0000-0001-9241-7038
Jeong-Hyeon KimDepartment of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea.
Yi YangCollege of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, 255 Jungang-ro, Sunchon, Jeonnam 57922, Republic of Korea.
İsa TaşCollege of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, 255 Jungang-ro, Sunchon, Jeonnam 57922, Republic of Korea.ORCID 0000-0001-5306-8584
So-Yeon ParkCollege of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, 255 Jungang-ro, Sunchon, Jeonnam 57922, Republic of Korea.ORCID 0000-0001-6663-8160
Rui ZhouCollege of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, 255 Jungang-ro, Sunchon, Jeonnam 57922, Republic of Korea.
Sultan PulatCollege of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, 255 Jungang-ro, Sunchon, Jeonnam 57922, Republic of Korea.ORCID 0000-0001-9871-8296
Mücahit VarlıCollege of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, 255 Jungang-ro, Sunchon, Jeonnam 57922, Republic of Korea.ORCID 0000-0001-6175-4015
Jae-Seoun HurKorean Lichen Research Institute, Sunchon National University, 255 Jungang-ro, Sunchon, Jeonnam 57922, Republic of Korea.ORCID 0000-0001-8547-7075
Sang-Jip NamDepartment of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea.
Hangun KimCollege of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, 255 Jungang-ro, Sunchon, Jeonnam 57922, Republic of Korea.ORCID 0000-0001-5889-8907
Sunchon National University · KREwha Womans University · KR

Funding

National Research Foundation of Korea NRF-2020R1C1C1007832
6 · The paper itself

Abstract

Colorectal cancer (CRC) is the third most deadly type of cancer in the world and continuous investigations are required to discover novel therapeutics for CRC. Induction of apoptosis is one of the promising strategies to inhibit cancers. Here, we have identified a novel compound, Libertellenone T (

Indexed as

apoptosisautophagyCRCG2/M phase arrestLibertellenone TROS/JNK signaling

Identifiers

PMID36672439
PMCPMC9857212
OpenAlexW4316039772

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.