Evidence map›Paper›PMID 36672700›Full record

ArticleBiomedicines2023

Effects of Transient Administration of the NMDA Receptor Antagonist MK-801 in

Thiago C Moulin, Tijana Stojanovic, Rasika P Rajesh, Tirusha Pareek, Laura Donzelli, Michael J Williams, Helgi B Schiöth

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Thiago C MoulinDepartment of Surgical Sciences, Division of Functional Pharmacology and Neuroscience, Uppsala University, 751 24 Uppsala, Sweden.ORCID 0000-0001-7811-5383
Tijana StojanovicDepartment of Surgical Sciences, Division of Functional Pharmacology and Neuroscience, Uppsala University, 751 24 Uppsala, Sweden.
Rasika P RajeshDepartment of Surgical Sciences, Division of Functional Pharmacology and Neuroscience, Uppsala University, 751 24 Uppsala, Sweden.ORCID 0000-0002-2807-6985
Tirusha PareekDepartment of Surgical Sciences, Division of Functional Pharmacology and Neuroscience, Uppsala University, 751 24 Uppsala, Sweden.
Laura DonzelliDepartment of Surgical Sciences, Division of Functional Pharmacology and Neuroscience, Uppsala University, 751 24 Uppsala, Sweden.ORCID 0000-0001-5617-5297
Michael J WilliamsDepartment of Surgical Sciences, Division of Functional Pharmacology and Neuroscience, Uppsala University, 751 24 Uppsala, Sweden.
Helgi B SchiöthDepartment of Surgical Sciences, Division of Functional Pharmacology and Neuroscience, Uppsala University, 751 24 Uppsala, Sweden.
Uppsala University · SE

Funding

European Union's Horizon 2020 857394Gunvor och Josef Anérs stiftelse FB20-0102Royal Physiographic Society Lund NASwedish Research Council 2019-01066Uppsala University Ingegerd Bergh and Kungl Vetenskapssamh stipends
6 · The paper itself

Abstract

MK-801, also called dizocilpine, is an N-methyl-D-aspartate (NMDA) receptor antagonist widely used in animal research to model schizophrenia-like phenotypes. Although its effects in rodents are well characterised, little is known about the outcomes of this drug in other organisms. In this study, we characterise the effects of MK-801 on the locomotion, sleep, and negative geotaxis of the fruit fly

Indexed as

circadian activityclimbing behaviordizocilpinefruit flyglutamate receptorinvertebratespsychiatric modelstranslational models

Identifiers

PMID36672700
PMCPMC9855773
OpenAlexW4315781175

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.