ArticleGenes2022
Sex Differences in the Association between Risk of Anterior Cruciate Ligament Rupture and COL5A1 Polymorphisms in Elite Footballers.
Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- The Role ofGenes · 2026Pooled it
- Socceromics: A Systematic Review of Omics Technologies to Optimize Performance and Health in Soccer.International journal of molecular sciences · 2026Pooled it
- Pooled it
- An Evidence-Based and Mechanistic Approach to Reducing the Risk of Anterior Cruciate Ligament Injury: An Exercise and Sport Science Australia Position Statement.Sports medicine (Auckland, N.Z.) · 2026Article
- Weighted total genotype score associated with knee ligament injury incidence in adolescent female basketball athletes.BMC sports science, medicine & rehabilitation · 2026Article
- Collagen Type V alpha 1 chain and alpha-actinin-3 variants predict knee ligament injury risk in professional football players.Journal of experimental orthopaedics · 2026Article
- Age is not a primary risk factor for anterior cruciate ligament injury-A comprehensive review of anterior cruciate ligament injury and reinjury risk factors confounded by young patient age.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Review
- Strategies for preventing anterior cruciate ligament injuries in athletes: Insights from a scoping review.Journal of orthopaedics · 2025Review
- Association Between theGenes · 2025Article
- Anatomical Tissue Engineering of the Anterior Cruciate Ligament Entheses.International journal of molecular sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSingle-nucleotide polymorphisms (SNPs) in collagen genes are predisposing factors for anterior cruciate ligament (ACL) rupture. Although these events are more frequent in females, the sex-specific risk of reported SNPs has not been evaluated. PURPOSE: We aimed to assess the sex-specific risk of historic non-contact ACL rupture considering candidate SNPs in genes previously associated with muscle, tendon, ligament and ACL injury in elite footballers. STUDY
designThis was a cohort genetic association study.
methodsForty-six (twenty-four females) footballers playing for the first team of FC Barcelona (Spain) during the 2020-21 season were included in the study. We evaluated the association between a history of non-contact ACL rupture before July 2022 and 108 selected SNPs, stratified by sex. SNPs with nominally significant associations in one sex were then tested for their interactions with sex on ACL.
resultsSeven female (29%) and one male (4%) participants had experienced non-contact ACL rupture during their professional football career before the last date of observation. We found a significant association between the rs13946 C/C genotype and ACL injury in women footballers (
conclusionsThe present study suggests the role of SNPs in genes encoding for collagens as female risk factors for ACL injury in football players. CLINICAL RELEVANCE: The genetic profiling of athletes at high risk of ACL rupture can contribute to sex-specific strategies for injury prevention in footballers.
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