Evidence map›Paper›PMID 36672843›Full record

Trial reportGenes2022

Walking Training Increases microRNA-126 Expression and Muscle Capillarization in Patients with Peripheral Artery Disease.

Natan D da Silva, Aluisio Andrade-Lima, Marcel R Chehuen, Anthony S Leicht, Patricia C Brum, Edilamar M Oliveira, Nelson Wolosker, Bruno R A Pelozin, Tiago Fernandes, Cláudia L M Forjaz

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. New horizons in nuclear cardiology: Imaging of peripheral arterial disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Natan D da SilvaExercise Hemodynamic Laboratory, School of Physical Education and Sport, University of São Paulo, São Paulo 05508-900, Brazil.ORCID 0000-0001-5689-9535
Aluisio Andrade-LimaExercise Hemodynamic Laboratory, School of Physical Education and Sport, University of São Paulo, São Paulo 05508-900, Brazil.
Marcel R ChehuenExercise Hemodynamic Laboratory, School of Physical Education and Sport, University of São Paulo, São Paulo 05508-900, Brazil.
Anthony S LeichtSport & Exercise Science, James Cook University, Townsville, QLD 4811, Australia.ORCID 0000-0002-0537-5392
Patricia C BrumCellular Molecular Exercise Physiology Laboratory, School of Physical Education and Sport, University of São Paulo, São Paulo 05508-900, Brazil.ORCID 0000-0002-4750-6506
Edilamar M OliveiraLaboratory of the Biochemistry and Molecular Biology of Exercise, School of Physical Education and Sport, University of São Paulo, São Paulo 05508-900, Brazil.ORCID 0000-0002-7101-312X
Nelson WoloskerAlbert Einstein Israelite Hospital, São Paulo 05652-900, Brazil.ORCID 0000-0003-1991-3507
Bruno R A PelozinLaboratory of the Biochemistry and Molecular Biology of Exercise, School of Physical Education and Sport, University of São Paulo, São Paulo 05508-900, Brazil.ORCID 0000-0002-9066-0488
Tiago FernandesLaboratory of the Biochemistry and Molecular Biology of Exercise, School of Physical Education and Sport, University of São Paulo, São Paulo 05508-900, Brazil.ORCID 0000-0002-9057-3878
Cláudia L M ForjazExercise Hemodynamic Laboratory, School of Physical Education and Sport, University of São Paulo, São Paulo 05508-900, Brazil.ORCID 0000-0001-7584-4265
Universidade de São Paulo · BRHospital Israelita Albert Einstein · BRJames Cook University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with peripheral artery disease (PAD) have reduced muscle capillary density. Walking training (WT) is recommended for PAD patients. The goal of the study was to verify whether WT promotes angiogenesis in PAD-affected muscle and to investigate the possible role of miRNA-126 and the vascular endothelium growth factor (VEGF) angiogenic pathways on this adaptation. Thirty-two men with PAD were randomly allocated to two groups: WT (

Indexed as

MicroRNAsPeripheral Arterial DiseaseHumansIntermittent ClaudicationMaleMuscle, SkeletalVascular Endothelial Growth Factor AWalkingMicroRNAsMIRN126 microRNA, humanVascular Endothelial Growth Factor Acapillarizationintermittent claudicationmicroRNAphysical exerciseVEGF

Identifiers

PMID36672843
PMCPMC9858623
OpenAlexW4313361075

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.