Evidence map›Paper›PMID 36674790›Full record

ReviewInternational journal of molecular sciences2023

Pretreated Mesenchymal Stem Cells and Their Secretome: Enhanced Immunotherapeutic Strategies.

Yuran Su, Chenyu Xu, Wen Cheng, Yanmei Zhao, Lei Sui, Yanhong Zhao

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
21.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yuran SuDepartment of Prosthodontics, School and Hospital of Stomatology, Tianjin Medical University, Tianjin 30070, China.ORCID 0000-0003-1695-5779
Chenyu XuDepartment of Orthodontics, School and Hospital of Stomatology, Tianjin Medical University, Tianjin 30070, China.
Wen ChengDepartment of Orthodontics, School and Hospital of Stomatology, Tianjin Medical University, Tianjin 30070, China.
Yanmei ZhaoInstitute of Disaster and Emergency Medicine, Tianjin University, Tianjin 30070, China.ORCID 0000-0002-8572-6470
Lei SuiDepartment of Prosthodontics, School and Hospital of Stomatology, Tianjin Medical University, Tianjin 30070, China.
Yanhong ZhaoDepartment of Orthodontics, School and Hospital of Stomatology, Tianjin Medical University, Tianjin 30070, China.
Tianjin Medical University · CNTianjin University · CN

Funding

National Natural Science Foundation of China 81871782National Natural Science Foundation of China 82072435Natural Science Foundation of Tianjin 21JCYBJC01760
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) with self-renewing, multilineage differentiation and immunomodulatory properties, have been extensively studied in the field of regenerative medicine and proved to have significant therapeutic potential in many different pathological conditions. The role of MSCs mainly depends on their paracrine components, namely secretome. However, the components of MSC-derived secretome are not constant and are affected by the stimulation MSCs are exposed to. Therefore, the content and composition of secretome can be regulated by the pretreatment of MSCs. We summarize the effects of different pretreatments on MSCs and their secretome, focusing on their immunomodulatory properties, in order to provide new insights for the therapeutic application of MSCs and their secretome in inflammatory immune diseases.

Indexed as

Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationImmunotherapyRegenerative MedicineSecretomeimmuomodulationinflammatory diseasesmesenchymal stem cellspretreatmentsecretome

Identifiers

PMID36674790
PMCPMC9864323
OpenAlexW4313891146

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.