Evidence map›Paper›PMID 36674890›Full record

ArticleInternational journal of molecular sciences2023

Advanced Glycation End Products and Activation of Toll-like Receptor-2 and -4 Induced Changes in Aquaporin-3 Expression in Mouse Keratinocytes.

Yonghong Luo, Rawipan Uaratanawong, Vivek Choudhary, Mary Hardin, Catherine Zhang, Samuel Melnyk, Xunsheng Chen, Wendy B Bollag

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Yonghong LuoDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Rawipan UaratanawongDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Vivek ChoudharyDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-3664-5025
Mary HardinDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Catherine ZhangDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Samuel MelnykDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Xunsheng ChenDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Wendy B BollagDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-3146-162X
Augusta University · US

Funding

BLRD VA IK6 BX005691CSRD VA I01 CX001357VA CX001357 and BX005691
6 · The paper itself

Abstract

Prolonged inflammation and impaired re-epithelization are major contributing factors to chronic non-healing diabetic wounds; diabetes is also characterized by xerosis. Advanced glycation end products (AGEs), and the activation of toll-like receptors (TLRs), can trigger inflammatory responses. Aquaporin-3 (AQP3) plays essential roles in keratinocyte function and skin wound re-epithelialization/re-generation and hydration. Suberanilohydroxamic acid (SAHA), a histone deacetylase inhibitor, mimics the increased acetylation observed in diabetes. We investigated the effects of TLR2/TLR4 activators and AGEs on keratinocyte AQP3 expression in the presence and absence of SAHA. Primary mouse keratinocytes were treated with or without TLR2 agonist Pam

Indexed as

Aquaporin 3Toll-Like Receptor 2AnimalsGlycation End Products, AdvancedKeratinocytesLipopolysaccharidesMiceToll-Like Receptor 4VorinostatAquaporin 3Glycation End Products, AdvancedLipopolysaccharidesToll-Like Receptor 2Toll-Like Receptor 4Vorinostatadvanced glycation end products (AGEs)aquaporin-3 (AQP3)diabeteshistone deacetylase inhibitorinflammationkeratinocytesskinTLR4toll-like receptor-2 (TLR2)

Identifiers

PMID36674890
PMCPMC9864132
OpenAlexW4315650941

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.