Evidence map›Paper›PMID 36674969›Full record

ArticleInternational journal of molecular sciences2023

Global Impairment of Immediate-Early Genes Expression in Rett Syndrome Models and Patients Linked to Myelination Defects.

Paolo Petazzi, Olga Caridad Jorge-Torres, Antonio Gomez, Iolanda Scognamiglio, Jordi Serra-Musach, Angelika Merkel, Daniela Grases, Clara Xiol, Mar O'Callaghan, Judith Armstrong and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Promoter mutagenesis and a massively parallel reporter screen of thebioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Paolo PetazziJosep Carreras Leukemia Research Institute, School of Medicine, University of Barcelona, Carrer Casanova 143, 400° floor, 08036 Barcelona, Spain.ORCID 0000-0002-1036-2895
Olga Caridad Jorge-TorresJosep Carreras Leukaemia Research Institute (IJC), Badalona, 08916 Barcelona, Spain.ORCID 0000-0002-1219-8865
Antonio GomezBiosciences Department, Faculty of Sciences and Technology (FCT), University of Vic-Central University of Catalonia (UVic-UCC), C. de la Laura, 13, 08500 Vic, Spain.
Iolanda ScognamiglioCancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, 08908 Barcelona, Spain.
Jordi Serra-MusachCancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, 08908 Barcelona, Spain.
Angelika MerkelJosep Carreras Leukaemia Research Institute (IJC), Badalona, 08916 Barcelona, Spain.ORCID 0000-0001-5164-6803
Daniela GrasesJosep Carreras Leukaemia Research Institute (IJC), Badalona, 08916 Barcelona, Spain.
Clara XiolFundación San Juan de Dios, 08950 Barcelona, Spain.ORCID 0000-0001-7013-554X
Mar O'CallaghanClínica Rett, Neurology Department, Hospital Sant Joan de Déu, 08950 Barcelona, Spain.ORCID 0000-0002-1896-1622
Judith ArmstrongServei de Medicina Genètica i Molecular, Institut de Recerca Pediàtrica, Hospital Sant Joan de Déu, 08950 Barcelona, Spain.ORCID 0000-0003-0588-9307
Manel EstellerJosep Carreras Leukaemia Research Institute (IJC), Badalona, 08916 Barcelona, Spain.ORCID 0000-0003-4490-6093
Sonia GuilJosep Carreras Leukaemia Research Institute (IJC), Badalona, 08916 Barcelona, Spain.ORCID 0000-0002-2257-3331
Josep Carreras Leukaemia Research Institute · ESHospital Sant Joan de Déu Barcelona · ESInstitut d'Investigació Biomédica de Bellvitge · ESInstitució Catalana de Recerca i Estudis Avançats · ESInstituto de Salud Carlos III · ESUniversitat de Vic - Universitat Central de Catalunya · ES

Funding

FinRettHealth and Science Departments of the Catalan Government
6 · The paper itself

Abstract

Rett syndrome (RTT) is a severe neurodevelopmental disease caused almost exclusively by mutations to the

Indexed as

Rett SyndromeAnimalsBrainDisease Models, AnimalGenes, Immediate-EarlyHippocampusMammalsMethyl-CpG-Binding Protein 2MiceNeuronsMethyl-CpG-Binding Protein 2EGR2IEGsMeCP2myelinationRett syndrome

Identifiers

PMID36674969
PMCPMC9864472
OpenAlexW4315796240

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.