Evidence map›Paper›PMID 36675131›Full record

ArticleInternational journal of molecular sciences2023

5-Methylcytosine and 5-Hydroxymethylcytosine in Scrapie-Infected Sheep and Mouse Brain Tissues.

Adelaida Hernaiz, Sara Sentre, Marina Betancor, Óscar López-Pérez, Mónica Salinas-Pena, Pilar Zaragoza, Juan José Badiola, Janne Markus Toivonen, Rosa Bolea, Inmaculada Martín-Burriel

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Adelaida HernaizLaboratorio de Genética Bioquímica (LAGENBIO), Facultad de Veterinaria, Universidad de Zaragoza, IA2, IIS Aragón, 50013 Zaragoza, Spain.ORCID 0000-0002-6806-9990
Sara SentreLaboratorio de Genética Bioquímica (LAGENBIO), Facultad de Veterinaria, Universidad de Zaragoza, IA2, IIS Aragón, 50013 Zaragoza, Spain.
Marina BetancorCentro de Encefalopatías y Enfermedades Transmisibles Emergentes (CEETE), Facultad de Veterinaria, Universidad de Zaragoza, IA2, IIS Aragón, 50013 Zaragoza, Spain.ORCID 0000-0002-0388-9429
Óscar López-PérezLaboratorio de Genética Bioquímica (LAGENBIO), Facultad de Veterinaria, Universidad de Zaragoza, IA2, IIS Aragón, 50013 Zaragoza, Spain.ORCID 0000-0003-2454-2114
Mónica Salinas-PenaLaboratorio de Genética Bioquímica (LAGENBIO), Facultad de Veterinaria, Universidad de Zaragoza, IA2, IIS Aragón, 50013 Zaragoza, Spain.
Pilar ZaragozaLaboratorio de Genética Bioquímica (LAGENBIO), Facultad de Veterinaria, Universidad de Zaragoza, IA2, IIS Aragón, 50013 Zaragoza, Spain.
Juan José BadiolaCentro de Encefalopatías y Enfermedades Transmisibles Emergentes (CEETE), Facultad de Veterinaria, Universidad de Zaragoza, IA2, IIS Aragón, 50013 Zaragoza, Spain.
Janne Markus ToivonenLaboratorio de Genética Bioquímica (LAGENBIO), Facultad de Veterinaria, Universidad de Zaragoza, IA2, IIS Aragón, 50013 Zaragoza, Spain.ORCID 0000-0002-7243-1737
Rosa BoleaCentro de Encefalopatías y Enfermedades Transmisibles Emergentes (CEETE), Facultad de Veterinaria, Universidad de Zaragoza, IA2, IIS Aragón, 50013 Zaragoza, Spain.
Inmaculada Martín-BurrielLaboratorio de Genética Bioquímica (LAGENBIO), Facultad de Veterinaria, Universidad de Zaragoza, IA2, IIS Aragón, 50013 Zaragoza, Spain.ORCID 0000-0001-6016-4726
Universidad de Zaragoza · ES

Funding

European Social Fund predoctoral grant Order IIU/2023/2017Gobierno de Aragón 19-20R-LAGENBIO Consolidated GroupGobierno de Aragón predoctoral grant Order IIU/2023/2017Spanish Ministry of Economy and Competitiveness and FEDER Funds AGL2015-67945-P
6 · The paper itself

Abstract

Scrapie is a neurodegenerative disorder belonging to the group of transmissible spongiform encephalopathies or prion diseases, which are caused by an infectious isoform of the innocuous cellular prion protein (PrP

Indexed as

BrainPrionsScrapie5-MethylcytosineAnimalsDNA-Binding ProteinsDNA MethylationDNA Methyltransferase 3BEpigenesis, GeneticHistone Deacetylase 1Histone Deacetylase 2MicePrion DiseasesProto-Oncogene ProteinsSheep5-hydroxymethylcytosine5-MethylcytosineDNA-Binding ProteinsDNA Methyltransferase 3BHdac1 protein, mouseHistone Deacetylase 1Histone Deacetylase 2PrionsProto-Oncogene ProteinsTET1 protein, mouse5-hydroxymethylcytosine5-methylcytosineprion diseasesscrapie

Identifiers

PMID36675131
PMCPMC9864596
OpenAlexW4315865206

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.