Evidence map›Paper›PMID 36675784›Full record

ArticleJournal of personalized medicine2023

Host Genetic Variants Linked to COVID-19 Neurological Complications and Susceptibility in Young Adults-A Preliminary Analysis.

Anastasiya Kazantseva, Renata Enikeeva, Zalina Takhirova, Yuliya Davydova, Rustam Mustafin, Sergey Malykh, Alexandra Karunas, Alexander Kanapin, Elza Khusnutdinova

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Anastasiya KazantsevaInstitute of Biochemistry and Genetics-Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, 450054 Ufa, Russia.
Renata EnikeevaInstitute of Biochemistry and Genetics-Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, 450054 Ufa, Russia.
Zalina TakhirovaLaboratory of Neurocognitive Genomics, Department of Genetics and Fundamental Medicine, Ufa University of Science and Technology, 450076 Ufa, Russia.
Yuliya DavydovaInstitute of Biochemistry and Genetics-Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, 450054 Ufa, Russia.ORCID 0000-0003-3508-4710
Rustam MustafinDepartment of Medical Genetics and Fundamental Medicine, Bashkir State Medical University, 450008 Ufa, Russia.
Sergey MalykhPsychological Institute, Russian Academy of Education, 125009 Moscow, Russia.ORCID 0000-0002-3786-7447
Alexandra KarunasInstitute of Biochemistry and Genetics-Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, 450054 Ufa, Russia.
Alexander KanapinLaboratory of Neurocognitive Genomics, Department of Genetics and Fundamental Medicine, Ufa University of Science and Technology, 450076 Ufa, Russia.
Elza KhusnutdinovaInstitute of Biochemistry and Genetics-Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, 450054 Ufa, Russia.ORCID 0000-0003-2987-3334
Ufa Institute of Chemistry · RUBashkir State Medical University · RULomonosov Moscow State University · RUPeter the Great St. Petersburg Polytechnic University · RU

Funding

the Ministry of Science and Higher Education of Russian Federation grant number 075-15-2021-595the Ministry of Science and Higher Education of the Republic of Bashkortostan agreement no. 1, December 2, 2022the Program of Bioresource Collections of the FASO of Russia 007-030164/2, the "Collection of Biological Materials of Human Beings" of the IBG UFRC RASthe Russian Science Foundation grant number 17-78-30028
6 · The paper itself

Abstract

To date, multiple efforts have been made to use genome-wide association studies (GWAS) to untangle the genetic basis for SARS-CoV-2 infection susceptibility and severe COVID-19. However, data on the genetic-related effects of SARS-CoV-2 infection on the presence of accompanying and long-term post-COVID-19 neurological symptoms in younger individuals remain absent. We aimed to examine the possible association between SNPs found in a GWAS of COVID-19 outcomes and three phenotypes: SARS-CoV-2 infection, neurological complications during disease progression, and long-term neurological complications in young adults with a mild-to-moderate disease course. University students (N = 336, age 18-25 years, European ancestry) with or without COVID-19 and neurological symptoms in anamnesis comprised the study sample. Logistic regression was performed with COVID-19-related phenotypes as outcomes, and the top 25 SNPs from GWAS meta-analyses and an MR study linking COVID-19 and cognitive deficits were found. We replicated previously reported associations of the

Indexed as

coronavirusCOVID-19genegenome-wide association study (GWAS)mental healthneurological symptoms

Identifiers

PMID36675784
PMCPMC9860613
OpenAlexW4313823825

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.