Evidence map›Paper›PMID 36677658›Full record

ReviewMolecules (Basel, Switzerland)2023

A Comprehensive Review on Bio-Based Materials for Chronic Diabetic Wounds.

Jinjin Pei, Chella Perumal Palanisamy, Phaniendra Alugoju, Naga Venkata Anusha Anthikapalli, Prabhu Manickam Natarajan, Vidhya Rekha Umapathy, Bhuminathan Swamikannu, Selvaraj Jayaraman, Ponnulakshmi Rajagopal, Sirilux Poompradub

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Skin Organoids in Diabetic Chronic Wounds: Current Status and Future Perspectives.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Applications and prospects of biomaterials in diabetes management.Frontiers in bioengineering and biotechnology · 2025
    Review
  7. Novel design and development ofRegenerative therapy · 2024
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 4 countries.

Jinjin PeiQinba State Key Laboratory of Biological Resources and Ecological Environment, 2011 QinLing-Bashan Mountains Bioresources Comprehensive Development C. I. C, Shaanxi Province Key Laboratory of Bioresources, College of Bioscience and Bioengineering, Shaanxi University of Technology, Hanzhong 723001, China.
Chella Perumal PalanisamyDepartment of Chemical Technology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0002-3527-3477
Phaniendra AlugojuNatural Products for Neuroprotection and Anti-Ageing Research Unit, Chulalongkorn University, Bangkok 10330, Thailand.
Naga Venkata Anusha AnthikapalliDepartment of Chemistry, A.N.R College, Gudivada, Andhra Pradesh 521301, India.
Prabhu Manickam NatarajanDepartment of Clinical Sciences, Center of Medical and Bio-allied Health Sciences and Research, Ajman University, Ajman 346, United Arab Emirates.ORCID 0000-0002-4780-0465
Vidhya Rekha UmapathyDepartment of Public Health Dentistry, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai 600100, India.ORCID 0000-0002-8603-9373
Bhuminathan SwamikannuDepartment of Prosthodontics, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai 600100, India.
Selvaraj JayaramanCentre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College & Hospital, Saveetha Institute of Medical & Technical Sciences, Chennai 600077, India.
Ponnulakshmi RajagopalCentral Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai 600078, India.
Sirilux PoompradubDepartment of Chemical Technology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Chulalongkorn University · THSree Balaji Dental College and Hospital · INAjman University · AEGovernment Ayurved College, Nanded · INMeenakshi Academy of Higher Education and Research · INSaveetha University · INShaanxi University of Technology · CN

Funding

National Natural Science Foundation of China 31801563Sanqin Scholars Innovation Team and Second century fund (C2F), Chulalongkorn University, Bangkok, Thailand. 20084563
6 · The paper itself

Abstract

Globally, millions of people suffer from poor wound healing, which is associated with higher mortality rates and higher healthcare costs. There are several factors that can complicate the healing process of wounds, including inadequate conditions for cell migration, proliferation, and angiogenesis, microbial infections, and prolonged inflammatory responses. Current therapeutic methods have not yet been able to resolve several primary problems; therefore, their effectiveness is limited. As a result of their remarkable properties, bio-based materials have been demonstrated to have a significant impact on wound healing in recent years. In the wound microenvironment, bio-based materials can stimulate numerous cellular and molecular processes that may enhance healing by inhibiting the growth of pathogens, preventing inflammation, and stimulating angiogenesis, potentially converting a non-healing environment to an appropriately healing one. The aim of this present review article is to provide an overview of the mechanisms underlying wound healing and its pathophysiology. The development of bio-based nanomaterials for chronic diabetic wounds as well as novel methodologies for stimulating wound healing mechanisms are also discussed.

Indexed as

Diabetes MellitusNanostructuresCell MovementHumansInflammationWound Healingbiomaterialsdiabetic woundsnatural productswound healing

Identifiers

PMID36677658
PMCPMC9861360
OpenAlexW4313890305

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.