Evidence map›Paper›PMID 36677729›Full record

ArticleMolecules (Basel, Switzerland)2023

QuEChERS-Based Approach to the Extraction of Five Calcium Channel Blockers from Plasma Determined by UPLC-MS/MS.

Tingting Zhao, Wen Jiang, Xiaolan Zhen, Chengcheng Jin, Yifan Zhang, Hui Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Tingting ZhaoCollege of Pharmacy, Hebei Medical University, Shijiazhuang 050000, China.
Wen JiangCollege of Chemistry and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050000, China.
Xiaolan ZhenHebei Institute of Drug and Medical Device Inspection, Shijiazhuang 050000, China.
Chengcheng JinCollege of Chemistry and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050000, China.
Yifan ZhangCollege of Pharmacy, Hebei Medical University, Shijiazhuang 050000, China.
Hui LiCollege of Pharmacy, Hebei Medical University, Shijiazhuang 050000, China.
Hebei Medical University · CNHebei University of Science and Technology · CNHebei Food Inspection and Research Institute · CN

Funding

Natural Science Foundation of Hebei Province H2022329002
6 · The paper itself

Abstract

Here, a QuEChERS (quick, easy, cheap, effective, rugged, and safe) pretreatment method was combined with UPLC-MS/MS to facilitate the rapid and reliable simultaneous detection of five calcium channel blockers (CCBs) in human plasma. For this approach, samples were treated with 1 mL of acetonitrile, 350 mg of magnesium sulfate, and 70 mg of PSA adsorbent prior to centrifugation. Supernatants then underwent gradient elution for 8 min with an Agilent C18 column using an acetonitrile-water solution supplemented with 5 mmol⋅L

Indexed as

Calcium Channel BlockersTandem Mass SpectrometryAcetonitrilesChromatography, High Pressure LiquidChromatography, LiquidHumansAcetonitrilesCalcium Channel Blockerscalcium channel blockershuman plasmahypertensionQuEChERSUPLC-MS/MS

Identifiers

PMID36677729
PMCPMC9866929
OpenAlexW4313898512

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.