Evidence map›Paper›PMID 36680735›Full record

ReviewMolecular neurobiology2023

The Potential of NLRP3 Inflammasome as a Therapeutic Target in Neurological Diseases.

Wenfang He, Zhiping Hu, Yanjun Zhong, Chenfang Wu, Jinxiu Li

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wenfang HeDepartment of Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Zhiping HuDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, China.
Yanjun ZhongDepartment of Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Chenfang WuDepartment of Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Jinxiu LiDepartment of Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China. jinxiuli2021@csu.edu.cn.ORCID http://orcid.org/0000-0002-4174-1994
Central South University · CN

Funding

Natural Science Foundation of Hunan Province 2021JJ40832Scientific Research Project of Hunan Provincial Health Commission 202117010086
6 · The paper itself

Abstract

NLRP3 (NLRP3: NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome is the best-described inflammasome that plays a crucial role in the innate immune system and a wide range of diseases. The intimate association of NLRP3 with neurological disorders, including neurodegenerative diseases and strokes, further emphasizes its prominence as a clinical target for pharmacological intervention. However, after decades of exploration, the mechanism of NLRP3 activation remains indefinite. This review highlights recent advances and gaps in our insights into the regulation of NLRP3 inflammasome. Furthermore, we present several emerging pharmacological approaches of clinical translational potential targeting the NLRP3 inflammasome in neurological diseases. More importantly, despite small-molecule inhibitors of the NLRP3 inflammasome, we have focused explicitly on Chinese herbal medicine and botanical ingredients, which may be splendid therapeutics by inhibiting NLRP3 inflammasome for central nervous system disorders. We expect that we can contribute new perspectives to the treatment of neurological diseases.

Indexed as

Central Nervous System DiseasesStrokeHumansInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinProtein Processing, Post-TranslationalInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinAlzheimer’s diseaseChinese herbal medicineNeuroinflammationNeurological diseasesNLRP3 inflammasomeStroke

Identifiers

PMID36680735
OpenAlexW4317662919

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.