Evidence map›Paper›PMID 36684103›Full record

ReviewBioengineering & translational medicine2023

Electrically conductive carbon-based (bio)-nanomaterials for cardiac tissue engineering.

Negin Jalilinejad, Mohammad Rabiee, Nafiseh Baheiraei, Ramin Ghahremanzadeh, Reza Salarian, Navid Rabiee, Omid Akhavan, Payam Zarrintaj, Aleksander Hejna, Mohammad Reza Saeb and 4 more

Open access · goldAbstract readReview
In one paragraph

Review in Bioengineering & translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
8.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 101 citations in OpenAlex.

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  8. 3D Bioprinting Functional Engineered Heart Tissues.International journal of molecular sciences · 2025
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  12. Surgical Methods and Devices for Atrial Fibrillation.Reviews in cardiovascular medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 6 countries.

Negin JalilinejadBiomaterial Group, Department of Biomedical Engineering Amirkabir University of Technology Tehran Iran.
Mohammad RabieeBiomaterial Group, Department of Biomedical Engineering Amirkabir University of Technology Tehran Iran.
Nafiseh BaheiraeiTissue Engineering and Applied Cell Sciences Division, Department of Anatomical Sciences, Faculty of Medical Sciences Tarbiat Modares University Tehran Iran.
Ramin GhahremanzadehNanobiotechnology Research Center Avicenna Research Institute, ACECR Tehran Iran.
Reza SalarianBiomedical Engineering Department Maziar University Royan Mazandaran Iran.
Navid RabieeDepartment of Physics Sharif University of Technology Tehran Iran.ORCID https://orcid.org/0000-0002-6945-8541
Omid AkhavanDepartment of Physics Sharif University of Technology Tehran Iran.
Payam ZarrintajSchool of Chemical Engineering Oklahoma State University Stillwater Oklahoma USA.
Aleksander HejnaDepartment of Polymer Technology, Faculty of Chemistry Gdańsk University of Technology Gdańsk Poland.
Mohammad Reza SaebDepartment of Polymer Technology, Faculty of Chemistry Gdańsk University of Technology Gdańsk Poland.
Ali ZarrabiDepartment of Biomedical Engineering, Faculty of Engineering and Natural Sciences Istinye University Istanbul Turkey.ORCID https://orcid.org/0000-0003-0391-1769
Esmaeel SharifiDepartment of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies Hamadan University of Medical Sciences Hamadan Iran.ORCID https://orcid.org/0000-0003-3400-3106
Satar YousefiaslSchool of Dentistry Hamadan University of Medical Sciences Hamadan Iran.ORCID https://orcid.org/0000-0001-9876-6220
Ehsan Nazarzadeh ZareSchool of Chemistry Damghan University Damghan Iran.ORCID https://orcid.org/0000-0002-0446-4385
Amirkabir University of Technology · IRGdańsk University of Technology · PLHamedan University of Medical Sciences · IRAcademic Center for Education, Culture and Research · IRDamghan University · IRIstinye University · TROklahoma State University · USPohang University of Science and Technology · KRSharif University of Technology · IRTarbiat Modares University · IRUniversity of Mazandaran · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A proper self-regenerating capability is lacking in human cardiac tissue which along with the alarming rate of deaths associated with cardiovascular disorders makes tissue engineering critical. Novel approaches are now being investigated in order to speedily overcome the challenges in this path. Tissue engineering has been revolutionized by the advent of nanomaterials, and later by the application of carbon-based nanomaterials because of their exceptional variable functionality, conductivity, and mechanical properties. Electrically conductive biomaterials used as cell bearers provide the tissue with an appropriate microenvironment for the specific seeded cells as substrates for the sake of protecting cells in biological media against attacking mechanisms. Nevertheless, their advantages and shortcoming in view of cellular behavior, toxicity, and targeted delivery depend on the tissue in which they are implanted or being used as a scaffold. This review seeks to address, summarize, classify, conceptualize, and discuss the use of carbon-based nanoparticles in cardiac tissue engineering emphasizing their conductivity. We considered electrical conductivity as a key affecting the regeneration of cells. Correspondingly, we reviewed conductive polymers used in tissue engineering and specifically in cardiac repair as key biomaterials with high efficiency. We comprehensively classified and discussed the advantages of using conductive biomaterials in cardiac tissue engineering. An overall review of the open literature on electroactive substrates including carbon-based biomaterials over the last decade was provided, tabulated, and thoroughly discussed. The most commonly used conductive substrates comprising graphene, graphene oxide, carbon nanotubes, and carbon nanofibers in cardiac repair were studied.

Indexed as

carbon‐based biomaterialscardiac tissue engineeringgraphenegraphene oxidescaffoldsstem cells

Identifiers

PMID36684103
PMCPMC9842069
OpenAlexW4281848091

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.