Evidence map›Paper›PMID 36687764›Full record

ArticleProceedings. IEEE International Symposium on Biomedical Imaging2022

HIERARCHICAL BRAIN EMBEDDING USING EXPLAINABLE GRAPH LEARNING.

Haoteng Tang, Lei Guo, Xiyao Fu, Benjamin Qu, Paul M Thompson, Heng Huang, Liang Zhan

Abstract read
In one paragraph

Article in Proceedings. IEEE International Symposium on Biomedical Imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Bidirectional Mapping with Contrastive Learning on Multimodal Neuroimaging Data.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2023
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Haoteng TangDepartment of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, USA.
Lei GuoDepartment of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, USA.
Xiyao FuDepartment of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, USA.
Benjamin QuMission San Jose High School, Fremont, USA.
Paul M ThompsonInstitute for Neuroimaging and Informatics, University of Southern California, Marina del Rey, USA.
Heng HuangDepartment of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, USA.
Liang ZhanDepartment of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, USA.

Funding

Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7M
The Human Connectome Project (HCP)U01MH093765 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2010 to 2014
$12.1M
Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
A Storage Area Network for Structural and Functional Image AnalysisS10RR023401 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2009 to 2009
$2.0M
SILICON GRAPHICS PRISM EXTREME 128P/1TBS10RR023043 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI SORENSEN, ALMA GREGORY · 2006 to 2006
$1.5M
Connecting late-life depression and cognition with statistical physics based connectomics and sparse Frechet regressionRF1MH125928 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LEOW, ALEX, WU, YICHAO · 2021 to 2021
$1.3M
CRCNS: Investigating Brain Dynamics through the Lens of Statistical MechanicsR01AG071243 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEOW, ALEX, ZHAN, LIANG · 2020 to 2022
$882k
Computeserver Structural &Functional Image AnalysisS10RR019307 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2004 to 2004
$496k
NCRR NIH HHS S10 RR019307NCRR NIH HHS S10 RR023043NCRR NIH HHS S10 RR023401NIA NIH HHS R01 AG071243NIA NIH HHS U01 AG068057NIBIB NIH HHS P41 EB015896NIMH NIH HHS RF1 MH125928NIMH NIH HHS U01 MH093765
6 · The paper itself

Abstract

Brain networks have been extensively studied in neuroscience, to better understand human behavior, and to identify and characterize distributed brain abnormalities in neurological and psychiatric conditions. Several deep graph learning models have been proposed for brain network analysis, yet most current models lack interpretability, which makes it hard to gain any heuristic biological insights into the results. In this paper, we propose a new explainable graph learning model, named hierarchical brain embedding (HBE), to extract brain network representations based on the network community structure, yielding interpretable hierarchical patterns. We apply our new method to predict aggressivity, rule-breaking, and other standardized behavioral scores from functional brain networks derived using ICA from 1,000 young healthy subjects scanned by the Human Connectome Project. Our results show that the proposed HBE outperforms several state-of-the-art graph learning methods in predicting behavioral measures, and demonstrates similar hierarchical brain network patterns associated with clinical symptoms.

Indexed as

brain functional connectomeexplainable AIgraph learningHCPregression

Identifiers

PMID36687764
PMCPMC9851647

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.