Evidence mapPaperPMID 36689166Full record

ReviewApplied biochemistry and biotechnology2023

A Study on Multiple Facets of Apolipoprotein A1 Milano.

Farah Maarfi, Mohd Aslam Yusuf, Mohammad Faizan Ali Ahmad, Shahnawaz Rehman, Saloni Aswal, Deepti Dogra, Ajay Singh, Mohd Yasir Khan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Applied biochemistry and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Farah MaarfiDepartment of Biotechnology, School of Applied and Life Science (SALS), Uttaranchal University, Dehradun, 248007, Uttarakhand, India.
Mohd Aslam YusufDepartment of Biosciences, Integral University, Lucknow, 226026, India.
Mohammad Faizan Ali AhmadDepartment of Biosciences, Integral University, Lucknow, 226026, India.
Shahnawaz RehmanDepartment of Zoology, S.S. Faculty of Science, Mohammad Ali Jauhar University, Rampur, U. P, India.
Saloni AswalDepartment of Biotechnology, School of Applied and Life Science (SALS), Uttaranchal University, Dehradun, 248007, Uttarakhand, India.
Deepti DograDepartment of Biotechnology, School of Applied and Life Science (SALS), Uttaranchal University, Dehradun, 248007, Uttarakhand, India.
Ajay SinghDepartment of Chemistry, School of Applied and Life Science (SALS), Uttaranchal University, Dehradun, 248007, Uttarakhand, India.
Mohd Yasir KhanDepartment of Biotechnology, School of Applied and Life Science (SALS), Uttaranchal University, Dehradun, 248007, Uttarakhand, India. khanyasir707@gmail.com.ORCID http://orcid.org/0000-0003-1107-7428
Uttaranchal University · INIntegral University · INMohammad Ali Jauhar University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For several strategies formulated to prevent atherosclerosis, Apolipoprotein A1 Milano (ApoA1M) remains a prime target. ApoA1M has been reported to have greater efficiency in reducing the incidence of coronary artery diseases. Furthermore, recombinant ApoA1M based mimetic peptide exhibits comparatively greater atheroprotective potential, offers a hope in reducing the burden of atherosclerosis in in vivo model system. The aim of this review is to emphasize on some of the observed ApoA1M structural and functional effects that are clinically and therapeutically meaningful that might converge on the basic role of ApoA1M in reducing the chances of glycation assisted ailments in diabetes. We also hypothesize that the nonenzymatic glycation prone arginine amino acid of ApoA1 gets replaced with cysteine residue and the rate of ApoA1 glycation may decrease due to change substitution of amino acid. Therefore, to circumvent the effect of ApoA1M glycation, the related mechanism should be explored at the cellular and functional levels, especially in respective experimental disease model in vivo.

Indexed as

AtherosclerosisCoronary Artery DiseaseApolipoprotein A-IHumansApolipoprotein A-IApolipoprotein A1 MilanoArginineAtheroprotectiveCardiovascular diseasesGlycation

Identifiers

PMID36689166
OpenAlexW4317740380

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.