Evidence map›Paper›PMID 36690516›Full record

ArticleJournal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi2023

Outbreak investigation in a COVID-19 designated hospital: The combination of phylogenetic analysis and field epidemiology study suggesting airborne transmission.

Yi-Chia Huang, Hsiao-Chen Tu, Han-Yueh Kuo, Pei-Lan Shao, Yu-Nong Gong, Hui-Ying Weng, Hung-Yu Shu, Chiung-Hui Kuo, Po-Hsien Kuo, Chien-Hui Chien and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Yi-Chia HuangNational Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan; National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Hsiao-Chen TuInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.
Han-Yueh KuoNational Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan; National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: hykuo@hch.gov.tw.
Pei-Lan ShaoNational Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan; National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Yu-Nong GongResearch Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; International Master Degree Program for Molecular Medicine in Emergency Viral Infection, Collage of Medicine, Chang Gung University, Taoyuan, Taiwan.
Hui-Ying WengNational Yang-Ming University, Taipei, Taiwan; National Yang Ming Chiao Tung University, Taipei, Taiwan.
Hung-Yu ShuChang Jung Christian University, Tainan, Taiwan.
Chiung-Hui KuoNational Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan.
Po-Hsien KuoNational Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan; National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Chien-Hui ChienNational Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan.
Chen-Chi WuNational Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan.
Ding-Cheng Derrick ChanNational Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Department of Geriatrics and Gerontology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Meng-Kun TsaiNational Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan; National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Shih-Feng TsaiInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.
Chong-Jen YuNational Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan; National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: jefferycjyu@ntu.edu.tw.
National Taiwan University Hospital · TWNational Health Research Institutes · TWChang Gung University · TWChang Jung Christian University · TWNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHealthcare-associated COVID-19 infections caused by SARS-CoV-2 have increased morbidity and mortality. Hospitals and skilled nursing facilities (SNFs) have been challenged by infection control and management.

methodsThis case study presents an outbreak investigation in a COVID-19-designated hospital and a hospital-based SNF. Real-time polymerase chain reaction (PCR) and other studies were performed on samples obtained from SNF residents, hospital patients, and healthcare workers (HCWs). The results of the laboratory tests and field epidemiological data were analyzed. Genome sequencing and phylogenetic analysis of SARS-CoV-2 were performed to identify the associations between cases. The tracer gas was released and recorded by a thermal imaging camera to investigate the spatial relations within clusters.

resultsDuring the outbreak, 29 COVID-19 infections in 3 clusters were identified through hospital-wide, risk-guided, and symptom-driven PCR tests. This included 12 HCWs, 5 patients, and 12 SNF residents who had been hospitalized for at least 14 days. Serology tests did not identify any cases among the PCR-negative individuals. The phylogenetic analysis revealed that viral strains from the 3 clusters shared a common mutation of G3994T and were phylogenetically related, which suggested that this outbreak had a common source rather than multiple introductions from the community. Linked cases exhibited vertical spatial distribution, and the sulfur hexafluoride release test confirmed a potential airborne transmission.

conclusionsThis report addressed the advantage of a multi-disciplinary team in outbreak investigation. Identifying an airborne transmission within an outbreak highlighted the importance of regular maintenance of ventilation systems.

Indexed as

COVID-19Cross InfectionDisease OutbreaksHospitalsHumansPhylogenyReal-Time Polymerase Chain ReactionRespiratory Aerosols and DropletsSARS-CoV-2Airborne transmissionCOVID-19Infectious disease outbreaksPhylogenetic analysisSulfur hexafluoride

Identifiers

PMID36690516
PMCPMC9841729
OpenAlexW4316495899

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.