Evidence map›Paper›PMID 36693105›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Metabolic reprogramming underlies cavefish muscular endurance despite loss of muscle mass and contractility.

Luke Olsen, Michaella Levy, J Kyle Medley, Huzaifa Hassan, Brandon Miller, Richard Alexander, Emma Wilcock, Kexi Yi, Laurence Florens, Kyle Weaver and 10 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
27.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
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  5. Article
  6. Novel mechanisms of chemosensory adaptation to the cave environment.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Divergent 3D genome organization in livers of cave and surface morphs ofbioRxiv : the preprint server for biology · 2025
    Article
  10. Article
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  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. The cavefish Astyanax mexicanus.Nature methods · 2023
    Article
  18. Article
  19. Proteomics Analysis of R-Ras Deficiency in Oxygen Induced Retinopathy.International journal of molecular sciences · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 3 countries.

Luke OlsenStowers Institute for Medical Research, Kansas City, MO 64110.
Michaella LevyStowers Institute for Medical Research, Kansas City, MO 64110.
J Kyle MedleyStowers Institute for Medical Research, Kansas City, MO 64110.
Huzaifa HassanStowers Institute for Medical Research, Kansas City, MO 64110.
Brandon MillerStowers Institute for Medical Research, Kansas City, MO 64110.
Richard AlexanderStowers Institute for Medical Research, Kansas City, MO 64110.
Emma WilcockDepartment of Biology, Widener University, Chester, PA 19013.ORCID 0000-0002-9936-2700
Kexi YiStowers Institute for Medical Research, Kansas City, MO 64110.
Laurence FlorensStowers Institute for Medical Research, Kansas City, MO 64110.ORCID 0000-0002-9310-6650
Kyle WeaverStowers Institute for Medical Research, Kansas City, MO 64110.ORCID 0000-0002-3960-9177
Sean A McKinneyStowers Institute for Medical Research, Kansas City, MO 64110.ORCID 0000-0002-9740-6247
Robert PeußInstitute for Evolution and Biodiversity, University of Münster, Münster 48149, Germany.
Jenna PersonsStowers Institute for Medical Research, Kansas City, MO 64110.
Alexander KenziorStowers Institute for Medical Research, Kansas City, MO 64110.
Ernesto MaldonadoEvoDevo Research Group, Unidad Académica de Sistemas Arrecifales, Instituto de Ciencias del Mar y Limnología, Universidad Nacional Autónoma de México, Puerto Morelos, Quintana Roo 77580, Mexico.ORCID 0000-0002-9627-967X
Kym DelventhalStowers Institute for Medical Research, Kansas City, MO 64110.ORCID 0000-0003-0505-9792
Andrew GluesenkampCenter for Conservation and Research, San Antonio Zoo, San Antonio, TX 78212.
Edward MagerDepartment of Biological Sciences, Advanced Environmental Research Institute, University of North Texas, Denton, TX 76203.ORCID 0000-0001-8992-3095
David CoughlinDepartment of Biology, Widener University, Chester, PA 19013.ORCID 0000-0001-9816-2742
Nicolas RohnerStowers Institute for Medical Research, Kansas City, MO 64110.ORCID 0000-0003-3248-2772
Stowers Institute for Medical Research · USWidener University · USUniversidad Nacional Autónoma de México · MXUniversity of Münster · DEUniversity of North Texas · US

Funding

Starvation resistance and resilience of metabolic dysfunction in cavefishDP2AG071466 · NIA · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI ROHNER, NICOLAS · 2020 to 2020
$2.5M
Understanding complex trait architecture through population genomicsR01GM127872 · NIGMS · UNIVERSITY OF MINNESOTA · PI KEENE, ALEX C, MCGAUGH, SUZANNE · 2018 to 2021
$1.7M
NIA NIH HHS DP2 AG071466NIGMS NIH HHS R01 GM127872
6 · The paper itself

Abstract

Physical inactivity is a scourge to human health, promoting metabolic disease and muscle wasting. Interestingly, multiple ecological niches have relaxed investment into physical activity, providing an evolutionary perspective into the effect of adaptive physical inactivity on tissue homeostasis. One such example, the Mexican cavefish

Indexed as

CharacidaeAnimalsBiological EvolutionCavesGlycogenHumansMammalsMexicoMusclesGlycogenevolutionary physiologyphysical activityskeletal muscle metabolism

Identifiers

PMID36693105
PMCPMC9945943
OpenAlexW4317851253

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.