ArticleCommunications biology2023
Murine breast cancers disorganize the liver transcriptome in a zonated manner.
Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- The Spatial Redox-Metalloptosis Axis in Liver Disease: A Hypothesis on Regional Susceptibility to Ferroptosis and Cuproptosis.Antioxidants (Basel, Switzerland) · 2026Review
- EasySCP unveils extensive liver zonation at single-cell proteomics resolution.Nature communications · 2026Article
- Effects of a brown rice-derived supplement on physical, cognitive and mental health among adults and the role of the gut microbiota: study protocol for a longitudinal, double-blind, randomized, placebo-controlled trial.BMC complementary medicine and therapies · 2026Article
- DeepSpaceDB: a spatial transcriptomics atlas for interactive in-depth analysis of tissues and tissue microenvironments.Nucleic acids research · 2026Article
- Spatial Transcriptomics Reveals Distinct Architectures but Shared Vulnerabilities in Primary and Metastatic Liver Tumors.Cancers · 2025Article
- Reliable imputation of spatial transcriptomes with uncertainty estimation and spatial regularization.Patterns (New York, N.Y.) · 2024Article
- CHAI: consensus clustering through similarity matrix integration for cell-type identification.Briefings in bioinformatics · 2024Article
- CHAI: Consensus Clustering Through Similarity Matrix Integration for Cell-Type Identification.bioRxiv : the preprint server for biology · 2024Article
- Progressive, multi-organ, and multi-layered nature of cancer cachexia.Cancer science · 2024Review
- Compartmentalization, cooperation, and communication: The 3Cs of Hepatocyte zonation.Current opinion in cell biology · 2024Review
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The spatially organized gene expression program within the liver specifies hepatocyte functions according to their relative distances to the bloodstream (i.e., zonation), contributing to liver homeostasis. Despite the knowledge that solid cancers remotely disrupt liver homeostasis, it remains unexplored whether solid cancers affect liver zonation. Here, using spatial transcriptomics, we thoroughly investigate the abundance and zonation of hepatic genes in cancer-bearing mice. We find that breast cancers affect liver zonation in various distinct manners depending on biological pathways. Aspartate metabolism and triglyceride catabolic processes retain relatively intact zonation patterns, but the zonation of xenobiotic catabolic process genes exhibits a strong disruption. The acute phase response is induced in zonated manners. Furthermore, we demonstrate that breast cancers activate innate immune cells in particular neutrophils in distinct zonated manners, rather than in a uniform fashion within the liver. Collectively, breast cancers disorganize hepatic transcriptomes in zonated manners, thereby disrupting zonated functions of the liver.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.