Evidence map›Paper›PMID 36694091›Full record

ArticleClinical rheumatology2023

Proposal of a new diagnostic algorithm for adult-onset Still's disease.

Karima Daghor-Abbaci, Nadia Ait Hamadouche, Chafia Dahou Makhloufi, Farida Mechid, Fifi Otmani, Mohamed Makrelouf, Amel Otmane, Nourredine Smail, Malika Boucelma, Fatma Zohra Aissat and 14 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Clinical rheumatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Disease activity score for still's disease.Clinical rheumatology · 2024
    Article
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 7 institutions in 1 country.

Karima Daghor-AbbaciInternal Medicine Department, University of Algiers 1, Faculty of Medical Sciences, Benyoucef Benkhedda, Bab El Oued University Hospital Center, 16000, Bab El Oued City, Algiers, Algeria. abbacidaghor@gmail.com.ORCID http://orcid.org/0000-0002-5669-5759
Nadia Ait HamadoucheDepartment of Epidemiology, Bab El Oued University Hospital Center, Bab El Oued City, Algiers, Algeria.
Chafia Dahou MakhloufiRheumatology Department, Bab El Oued University Hospital Center, Bab El Oued City, Algiers, Algeria.
Farida MechidRheumatology Department, Bab El Oued University Hospital Center, Bab El Oued City, Algiers, Algeria.
Fifi OtmaniInternal Medicine Department, Mustapha Bacha University Hospital Center, 1st May City, Algiers, Algeria.
Mohamed MakreloufBiochemistry, Hemotology and Genetics Laboratory of Research, Bab El Oued University Hospital Center, Bab El Oued City, Algiers, Algeria.
Amel OtmaneBiochemistry, Hemotology and Genetics Laboratory of Research, Bab El Oued University Hospital Center, Bab El Oued City, Algiers, Algeria.
Nourredine SmailDepartment of Epidemiology, Mustapha Bacha University Hospital Center, 1st May City, Algiers, Algeria.
Malika BoucelmaInternal Medicine Department, Kouba University Hospital Center, Kouba City, Algiers, Algeria.
Fatma Zohra AissatInfectious Diseases Department, El Hadi Flici University Hospital Center, Casbah City, Algiers, Algeria.
Salima Lefkir-TeffianiRheumatology Department, Benimessous University Hospital Center, Algiers, Benimessous City, Algeria.
Bilel BenganaRheumatology Department, Benimessous University Hospital Center, Algiers, Benimessous City, Algeria.
Nadia BoukherisInternal Medicine Department, Annaba University Hospital Center, Annaba City, Algeria.
Amar TebaibiaInternal Medicine Department, Birtraria University Hospital Center, El Biar City, Algiers, Algeria.
Baya TaharbouchetInternal Medicine Department, Bouloughine University Hospital Center, Algiers, Bouloughine City, Algeria.
Soraya AyoubInternal Medicine Department, Benimessous University Hospital Center, Algiers, Benimessous City, Algeria.
Brahim BenzianeInternal Medicine Department, Laghouat University Hospital Center, Laghouat City, Algeria.
Nadia OumniaInternal Medicine Department, Zmirli University Hospital Center, El Harrache City, Algiers, Algeria.
Chafika HaouichetRheumatology Department, Douera University Hospital Center, Blida City, Algeria.
Fella HanniRheumatology Department, Benaknoun University Hospital Center, Benaknoun City, Algiers, Algeria.
Nazim LarabaInternal Medicine Department, University of Algiers 1, Faculty of Medical Sciences, Benyoucef Benkhedda, Bab El Oued University Hospital Center, 16000, Bab El Oued City, Algiers, Algeria.
Djennete HakemInternal Medicine Department, Mostaghanem University Hospital Center, Mostaghanem City, Algeria.
Nacera BenfenatkiInternal Medicine Department, Rouiba University Hospital Center, Rouiba City, Algiers, Algeria.
Abdelkrim BerrahInternal Medicine Department, University of Algiers 1, Faculty of Medical Sciences, Benyoucef Benkhedda, Bab El Oued University Hospital Center, 16000, Bab El Oued City, Algiers, Algeria.
Centre Hospitalo-Universitaire Bab El Oued · DZHôpital Mustapha Pacha · DZUniversity of Algiers Benyoucef Benkhedda · DZBadji Mokhtar-Annaba University · DZUniversity of Blida · DZUniversity of Bouira · DZUniversity of Laghouat · DZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study was performed to develop a new diagnostic algorithm for adult-onset Still's disease (AOSD).

methodsWe conducted a multicenter prospective nationwide case-control study in tertiary Internal Medicine, Rheumatology, and Infectious Diseases departments, to include successively patients with suspected AOSD based on the presence of two or more major criteria of Yamaguchi and/or Fautrel classifications. Patients were classified as AOSD or controls according to a predefined procedure. A receiving operating characteristic curve was used to determine the best cutoff value of the points-based score for disease classification. A diagnostic algorithm was developed to help the physician in the diagnostic approach.

resultsA total of 160 patients were included, 80 patients with AOSD and 60 controls with different diagnoses. Twenty patients with incomplete data were excluded. In the multivariate analysis, 6 items remained independently associated with AOSD diagnosis: typical rash (OR: 24.01, 3 points), fever ≥ 39 °C (OR: 17.34, 3 points), pharyngitis (OR: 10.23, 2 points), arthritis (OR: 9.01, 2 points), NLR ≥ 4 (OR: 11.10, 2 points), and glycosylated ferritin ≤ 20% (OR: 1.59, 1 point). AOSD should be considered if the patient satisfies 7 points with a sensitivity of 92.5%, specificity of 93.3%, and accuracy of 92.8% (area under the curve (AUC): 0.97 [95% CI: 0.94-0.99]). The present points-based score was more accurate and sensitive than the Yamaguchi classification (78.8%, 92.5%, p = 0.01) and Fautrel classification (76.3%, 92.5%, p = 0.004). A typical rash associated with a points-based score ≥ 7 points leads to a very likely disease.

conclusionThe proposed new algorithm could be a good diagnostic tool for adult-onset Still's disease in clinical practice and research. Key Points • A diagnostic algorithm was performed to help the physician in the diagnostic approach of AOSD. • The points-based score included in this algorithm had a high sensitivity and accuracy. • This diagnostic algorithm can be useful in the clinical research.

Indexed as

ExanthemaStill's Disease, Adult-OnsetAdultAlgorithmsCase-Control StudiesHumansProspective StudiesAdult-onset Still’s diseaseClassification criteriaDiagnostic algorithmGlycosylated ferritinNeutrophil-to-lymphocyte ratioTypical rash

Identifiers

PMID36694091
OpenAlexW4317876235

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.