ArticleJournal of chemical information and modeling2023
Modeling the Orthosteric Binding Site of the G Protein-Coupled Odorant Receptor OR5K1.
Article in Journal of chemical information and modeling, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Development of an Olfactory Receptor (OR5K1)-Based Biosensor for Pyrazine Detection in Foods.Foods (Basel, Switzerland) · 2026Article
- Elucidating odorant synergy in red wine: through olfactory receptor-based profiling.NPJ science of food · 2026Article
- Molecular simulation-based 3D structural construction of olfactory receptor with agonist binding.Journal of computer-aided molecular design · 2025Article
- Decoding the Molecular Mechanisms of Menthol Isomer Perception Based on Computational Simulations.Foods (Basel, Switzerland) · 2025Article
- Olfactory GPCRs through the lens of structural bioinformatics.Chemical senses · 2025Review
- TBM preferred to AlphaFold 3 for functional models of insect odorant receptors.Computational and structural biotechnology journal · 2025Article
- Identification of Olfactory Receptors Responding to Androstenone and the Key Structure Determinant in Domestic Pig.Current issues in molecular biology · 2024Article
- Article
- Deciphering olfactory receptor binding mechanisms: a structural and dynamic perspective on olfactory receptors.Frontiers in molecular biosciences · 2024Review
- Structure-Based Discovery of Mouse Trace Amine-Associated Receptor 5 Antagonists.Journal of chemical information and modeling · 2023Article
- Machine Learning-Based Modeling of Olfactory Receptors in Their Inactive State: Human OR51E2 as a Case Study.Journal of chemical information and modeling · 2023Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With approximately 400 encoding genes in humans, odorant receptors (ORs) are the largest subfamily of class A G protein-coupled receptors (GPCRs). Despite its high relevance and representation, the odorant-GPCRome is structurally poorly characterized: no experimental structures are available, and the low sequence identity of ORs to experimentally solved GPCRs is a significant challenge for their modeling. Moreover, the receptive range of most ORs is unknown. The odorant receptor OR5K1 was recently and comprehensively characterized in terms of cognate agonists. Here, we report two additional agonists and functional data of the most potent compound on two mutants, L104
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.