Evidence map›Paper›PMID 36697242›Full record

Trial reportNeurology2023

Genotype-Guided Dual Antiplatelet Therapy in Minor Stroke or Transient Ischemic Attack With a Single Small Subcortical Infarction.

Huihui Liu, Jing Jing, Anxin Wang, Qin Xu, Xia Meng, Hao Li, Zixiao Li, Yongjun Wang

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Contralateral hemispheric cerebral blood flow can predict short-term clinical outcomes in patients with recent small subcortical infarcts.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  6. Review
4 · The record

Corrections and comments

  • Commented on by
    2023
5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Huihui LiuFrom the Department of Neurology (H. Liu, J.J., A.W., Q.X., X.M., H. Li, Z.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases (H. Liu, J.J., A.W., Q.X., X.M., H. Li, Z.L., Y.W.), Beijing; and Department of Neurology and Suzhou Clinical Research Center of Neurological Disease (H. Liu), the Second Affiliated Hospital of Soochow University, China.ORCID 0000-0002-4761-2800
Jing JingFrom the Department of Neurology (H. Liu, J.J., A.W., Q.X., X.M., H. Li, Z.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases (H. Liu, J.J., A.W., Q.X., X.M., H. Li, Z.L., Y.W.), Beijing; and Department of Neurology and Suzhou Clinical Research Center of Neurological Disease (H. Liu), the Second Affiliated Hospital of Soochow University, China.
Anxin WangFrom the Department of Neurology (H. Liu, J.J., A.W., Q.X., X.M., H. Li, Z.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases (H. Liu, J.J., A.W., Q.X., X.M., H. Li, Z.L., Y.W.), Beijing; and Department of Neurology and Suzhou Clinical Research Center of Neurological Disease (H. Liu), the Second Affiliated Hospital of Soochow University, China. yongjunwang@ncrcnd.org.cn.
Qin XuFrom the Department of Neurology (H. Liu, J.J., A.W., Q.X., X.M., H. Li, Z.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases (H. Liu, J.J., A.W., Q.X., X.M., H. Li, Z.L., Y.W.), Beijing; and Department of Neurology and Suzhou Clinical Research Center of Neurological Disease (H. Liu), the Second Affiliated Hospital of Soochow University, China.
Xia MengFrom the Department of Neurology (H. Liu, J.J., A.W., Q.X., X.M., H. Li, Z.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases (H. Liu, J.J., A.W., Q.X., X.M., H. Li, Z.L., Y.W.), Beijing; and Department of Neurology and Suzhou Clinical Research Center of Neurological Disease (H. Liu), the Second Affiliated Hospital of Soochow University, China.
Hao LiFrom the Department of Neurology (H. Liu, J.J., A.W., Q.X., X.M., H. Li, Z.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases (H. Liu, J.J., A.W., Q.X., X.M., H. Li, Z.L., Y.W.), Beijing; and Department of Neurology and Suzhou Clinical Research Center of Neurological Disease (H. Liu), the Second Affiliated Hospital of Soochow University, China.
Zixiao LiFrom the Department of Neurology (H. Liu, J.J., A.W., Q.X., X.M., H. Li, Z.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases (H. Liu, J.J., A.W., Q.X., X.M., H. Li, Z.L., Y.W.), Beijing; and Department of Neurology and Suzhou Clinical Research Center of Neurological Disease (H. Liu), the Second Affiliated Hospital of Soochow University, China.ORCID 0000-0002-4713-5418
Yongjun WangFrom the Department of Neurology (H. Liu, J.J., A.W., Q.X., X.M., H. Li, Z.L., Y.W.), Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases (H. Liu, J.J., A.W., Q.X., X.M., H. Li, Z.L., Y.W.), Beijing; and Department of Neurology and Suzhou Clinical Research Center of Neurological Disease (H. Liu), the Second Affiliated Hospital of Soochow University, China. yongjunwang@ncrcnd.org.cn.
Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesSingle small subcortical infarction (SSSI) is an important stroke subtype. The optimal antiplatelet medication for patients with ischemic stroke with an SSSI is still unclear. We aimed to test the efficacy and safety of ticagrelor-aspirin in preventing stroke recurrence among patients with SSSI in the Ticagrelor or Clopidogrel with Aspirin in High-Risk Patients with Acute Nondisabling Cerebrovascular Events II (CHANCE-2) trial.

methodsIn the CHANCE-2 trial, patients with a minor stroke or TIA who carried

resultsAmong 2,143 eligible patients, 340 had the responsible ICAS, and 1,803 did not. Ticagrelor-aspirin reduced stroke recurrence among all patients with SSSI (hazard ratio [HR]: 0.55; 95% CI 0.38-0.78; DISCUSSION: In this prespecified substudy, ticagrelor-aspirin was superior to clopidogrel-aspirin in reducing the risk of stroke at 90 days among patients with SSSI who carried CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that ticagrelor and aspirin reduced the risk of stroke recurrence compared with clopidogrel with aspirin in adult patients with acute minor SSSI.

Indexed as

Ischemic Attack, TransientStrokeAdultAspirinCerebral InfarctionClopidogrelCytochrome P-450 CYP2C19Drug Therapy, CombinationGenotypeHumansPlatelet Aggregation InhibitorsTicagrelorTreatment OutcomeAspirinClopidogrelCytochrome P-450 CYP2C19Platelet Aggregation InhibitorsTicagrelor

Identifiers

PMID36697242
PMCPMC10115499
OpenAlexW4318017329

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.