ArticleBMC emergency medicine2023
Age-adjusted Charlson Comorbidity Index as effective predictor for in-hospital mortality of patients with cardiac arrest: a retrospective study.
Article in BMC emergency medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Factors Associated with Invasive Mechanical Ventilation Requirement in Older ICU Patients: The Roles of Frailty, Comorbidity, and Acute Illness Severity.Biomedicines · 2026Article
- Association between early body temperature dynamic trajectory and mortality and infection rates for patients with cardiac arrest in ICU: a retrospective study.Journal of thoracic disease · 2026Article
- Mortality risk estimation for autistic older adults: comparing novel machine-learning derived weights versus standard weights for the Charlson Comorbidity Index.Journal of comparative effectiveness research · 2026Article
- Non-invasive cerebral oxygenation and blood pressure neuromonitoring characterizes dynamic cerebrovascular autoregulation following cardiac arrest.Resuscitation plus · 2026Article
- Association between prolonged Emergency Department stay and Intensive Care Unit mortality among patients at a tertiary hospital in Ethiopia.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2026Article
- Article
- Association between admission serum phosphate levels and prognosis in post-cardiac arrest patients: a retrospective observational study.BMC cardiovascular disorders · 2026Observational
- High Bed Occupancy Rates in Internal Medicine Departments Are Associated with Lower Hand Hygiene Compliance.Medicina (Kaunas, Lithuania) · 2026Article
- Beyond Molecular Characterization: The Impact of Age-Adjusted Charlson Comorbidity Index in Glioblastoma Patients Treated with Radio or Radio-Chemotherapy.Journal of clinical medicine · 2025Article
- Interpretable Machine Learning Model Integrating Electrocardiographic and Acute Physiology Metrics for Mortality Prediction in Critical Ill Patients.Journal of clinical medicine · 2025Article
- Comorbidity burden in elderly high-grade glioma patients: impact on radiotherapy outcomes.BMC cancer · 2025Article
- The relationship between clinical subtypes, prognosis, and treatment in ICU patients with acute cholangitis using unsupervised machine learning methods.BMC infectious diseases · 2025Article
- Construction and validation of prognostic model for ICU mortality in cardiac arrest patients: an interpretable machine learning modeling approach.European journal of medical research · 2025Article
- Application of the comprehensive complication index and Clavien-Dindo complication classification in cardiac surgery: a retrospective study.BMC cardiovascular disorders · 2025Article
- Evaluation of Potential Drug-Drug Interactions, Polypharmacy, and Prescribing Patterns of NSAIDs Among the Older Adults in a Secondary Care Setting.Clinical interventions in aging · 2025Observational
- Study on influencing factors of age-adjusted Charlson comorbidity index in patients with Alzheimer's disease based on machine learning model.Frontiers in medicine · 2025Article
- In-hospital cardiac arrest in middle-income settings: A comprehensive analysis of clinical profiles and outcomes of both adults and pediatrics.Resuscitation plus · 2024Article
- Comparing the outcomes and costs of cardiac monitoring with implantable loop recorders and mobile cardiac outpatient telemetry following stroke using real-world evidence.Journal of comparative effectiveness research · 2024Article
- Relationship of oral bacterial number with medical hospitalization costs in analysis of Diagnosis Procedure Combination database from single institution in Japan.Scientific reports · 2024Article
- Observational
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundCardiac arrest is currently one of the leading causes of mortality in clinical practice, and the Charlson Comorbidity Index (CCI) is widely utilized to assess the severity of comorbidities. We aimed to evaluate the relationship between the age-adjusted CCI score and in-hospital mortality in intensive care unit (ICU) patients with the diagnosis of cardiac arrest, which is important but less explored previously.
methodsThis was a retrospective study including patients aged over 18 years from the MIMIC-IV database. We calculated the age-adjusted CCI using age information and ICD codes. The univariate analysis for varied predictors' differences between the survival and the non-survival groups was performed. In addition, a multiple factor analysis was conducted based on logistic regression analysis with the primary result set as hospitalization death. An additional multivariate regression analysis was conducted to estimate the influence of hospital and ICU stay.
resultsA total of 1772 patients were included in our study, with median age of 66, among which 705 (39.8%) were female. Amongst these patients, 963 (54.3%) died during the hospitalization period. Patients with higher age-adjusted CCI scores had a higher likelihood of dying during hospitalization (P < 0.001; OR: 1.109; 95% CI: 1.068-1.151). With the age-adjusted CCI incorporated into the predictive model, the area under the receiver operating characteristic curve was 0.794 (CI: 0.773-0.814), showing that the prediction model is effective. Additionally, patients with higher age-adjusted CCI scores stayed longer in the hospital (P = 0.026, 95% CI: 0.056-0.896), but there was no significant difference between patients with varied age-adjusted CCI scores on the days of ICU stay.
conclusionThe age-adjusted CCI is a valid indicator to predict death in ICU patients with cardiac arrest, which can offer enlightenment for both theory literatures and clinical practice.
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