ReviewHormones (Athens, Greece)2023
The role of the gastric fundus in glycemic control.
Review in Hormones (Athens, Greece), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Diagnostic performance of the triglyceride-glucose index in predicting occurrence of cancer: a meta-analysis.Frontiers in oncology · 2025Pooled it
- Endogenous Ghrelin Levels and Perception of Hunger: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- Mindfulness Meditation Reduces Stress and Hospital Stay in Gastrointestinal Tumor Patients During Perioperative Period.Medical science monitor : international medical journal of experimental and clinical research · 2024Trial
- Diabetes Remission After LRYGBP With and Without Fundus Resection: a Randomized Clinical Trial.Obesity surgery · 2023Trial
- Short- and Long-Term Outcomes of Subtotal Gastrectomy for Remnant Gastric Cancer: A Multicenter Study.Annals of gastroenterological surgery · 2026Article
- Endoscopy for Metabolic Diseases.Journal of clinical medicine · 2026Review
- Hormonal Alterations in Individuals with Obesity After Metabolic Bariatric Surgery: A Narrative Review.Medicina (Kaunas, Lithuania) · 2025Review
- Article
- Weight loss dynamics after laparoscopic sleeve gastrectomy: a retrospective single center analysis with age and preoperative weight stratification.Scientific reports · 2025Article
- Critical Time Points for Assessing Long-Term Clinical Response After Sleeve Gastrectomy-A Retrospective Study of Patients with 13-Year Follow-Up.Obesity surgery · 2025Article
- Evaluating the triglyceride glucose index as a predictive biomarker for osteoporosis in patients with type 2 diabetes.Frontiers in endocrinology · 2025Article
- Association between oxidative balance score and gallstone disease: a population-based study from NHANES.Frontiers in nutrition · 2025Article
- Life's Simple 7 and its impact on chronic bowel disorders: a study on constipation and diarrhea in the U.S. adult population.Frontiers in medicine · 2025Article
- Association between the dietary inflammatory index, bowel habits, and systemic serum inflammatory markers: insights from NHANES (2005-2010).Frontiers in nutrition · 2025Article
- Establishing a Prediction Model for Weight Loss Outcomes After LSG in Chinese Obese Patients with BMI ≥ 32.5 Kg/mDiabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- The roles of lifestyle factors and genetic risk in the association between night shift work and cholelithiasis: a prospective cohort study.Frontiers in endocrinology · 2025Article
- Advances in Perioperative Nutritional Management in Metabolic and Bariatric Surgery.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- High visceral adiposity and low skeletal muscle mass independently predict the development of acute cholecystitis in patients with gallstones: a retrospective cohort study.Frontiers in medicine · 2025Article
- Overweight is the main behavioral risk factor associated with colorectal cancer mortality in the Brazilian population: an ecological analysis.Scientific reports · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGhrelin, one of the most studied gut hormones, is mainly produced by the gastric fundus. Abundant evidence exists from preclinical and clinical studies underlining its contribution to glucose regulation. In the following narrative review, the role of the gastric fundus in glucose regulation is summarized and we investigate whether its resection enhances glycemic control.
methodsAn electronic search was conducted in the PubMed® database and in Google Scholar® using a combination of medical subject headings (MeSH). We examined types of metabolic surgery, including, in particular, gastric fundus resection, either as part of laparoscopic sleeve gastrectomy (LSG) or modified laparoscopic gastric bypass with fundus resection (LRYGBP + FR), and the contribution of ghrelin reduction to glucose regulation.
resultsFourteen human studies were judged to be eligible and included in this narrative review. Reduction of ghrelin levels after fundus resection might be related to early glycemic improvement before significant weight loss is achieved. Long-term data regarding the role of ghrelin reduction in glucose homeostasis are sparse.
conclusionThe exact role of ghrelin in achieving glycemic control is still ambiguous. Data from human studies reveal a potential contribution of ghrelin reduction to early glycemic improvement, although further well-designed studies are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.