Evidence map›Paper›PMID 36711024›Full record

ArticleJournal of oncology2023

LncRNA SNHG5 Suppresses Cell Migration and Invasion of Human Lung Adenocarcinoma via Regulation of Epithelial-Mesenchymal Transition.

Zhirong Li, Yipeng Wu, Cong Zhang, Suli Dai, Sisi Wei, Ruinian Zhao, Feng Gao, Lianmei Zhao, Baoen Shan

Open access · hybridAbstract read
In one paragraph

Article in Journal of oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Zhirong LiResearch Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, China.ORCID https://orcid.org/0000-0002-9379-6057
Yipeng WuResearch Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, China.ORCID https://orcid.org/0000-0003-3178-0321
Cong ZhangResearch Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, China.ORCID https://orcid.org/0000-0003-2736-988X
Suli DaiResearch Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, China.ORCID https://orcid.org/0000-0003-2337-1149
Sisi WeiResearch Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, China.ORCID https://orcid.org/0000-0001-5959-653X
Ruinian ZhaoResearch Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, China.ORCID https://orcid.org/0000-0001-6701-9716
Feng GaoDepartment of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China.ORCID https://orcid.org/0000-0003-2664-8019
Lianmei ZhaoResearch Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, China.ORCID https://orcid.org/0000-0002-9363-9588
Baoen ShanResearch Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, China.ORCID https://orcid.org/0000-0003-2182-2233
Hebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long noncoding RNAs (lncRNAs) are gradually being annotated as important regulators of multiple cellular processes. The goal of our study was to investigate the effects of the lncRNA small nucleolar RNA host gene 5 (SNHG5) in lung adenocarcinoma (LAD) and its underlying mechanisms. The findings revealed a substantial drop in SNHG5 expression in LAD tissues, which correlated with clinical-pathological parameters. Transcriptome sequencing analysis demonstrated that the inhibitory effect of SNHG5 was associated with cell adhesion molecules. Moreover, the expression of SNHG5 was shown to be correlated with epithelial-mesenchymal transition (EMT) markers in western blots and immunofluorescence. SNHG5 also had significant effects of antimigration and anti-invasion on LAD cells

Identifiers

PMID36711024
PMCPMC9879674
OpenAlexW4317494009

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.