Evidence map›Paper›PMID 36711657›Full record

ArticlebioRxiv : the preprint server for biology2023

Osteoblast-intrinsic defect in glucose metabolism impairs bone formation in type II diabetic mice.

Fangfang Song, Won Dong Lee, Tyler Marmo, Xing Ji, Chao Song, Xueyang Liao, Rebbeca Seeley, Lutian Yao, Haoran Liu, Fanxin Long

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Fangfang SongTranslational Research Program in Pediatric Orthopedics, Department of Surgery, The Children's Hospital of Philadelphia.
Won Dong LeeLewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Tyler MarmoTranslational Research Program in Pediatric Orthopedics, Department of Surgery, The Children's Hospital of Philadelphia.
Xing JiTranslational Research Program in Pediatric Orthopedics, Department of Surgery, The Children's Hospital of Philadelphia.
Chao SongTranslational Research Program in Pediatric Orthopedics, Department of Surgery, The Children's Hospital of Philadelphia.
Xueyang LiaoTranslational Research Program in Pediatric Orthopedics, Department of Surgery, The Children's Hospital of Philadelphia.
Rebbeca SeeleyTranslational Research Program in Pediatric Orthopedics, Department of Surgery, The Children's Hospital of Philadelphia.
Lutian YaoTranslational Research Program in Pediatric Orthopedics, Department of Surgery, The Children's Hospital of Philadelphia.
Haoran LiuDepartment of Computer Science, New Jersey Institute of Technology, Newark, NJ, USA.
Fanxin LongTranslational Research Program in Pediatric Orthopedics, Department of Surgery, The Children's Hospital of Philadelphia.
Children's Hospital of Philadelphia · USNew Jersey Institute of Technology · USPrinceton University · US

Funding

NIDDK NIH HHS R01 DK125498
6 · The paper itself

Abstract

Skeletal fragility is associated with type 2 diabetes mellitus (T2D), but the underlying mechanism is not well understood. Here, in a mouse model for youth-onset T2D, we show that both trabecular and cortical bone mass are reduced due to diminished osteoblast activity. Stable isotope tracing in vivo with

Identifiers

PMID36711657
PMCPMC9882117
OpenAlexW4317374081

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.